Maternal immune thrombocytopenic purpura (ITP) may lead to fetal platelet destruction. This process is mediated by IgG platelet autoantibodies that cross the placenta. In this case, not only were platelet autoantibodies present, but red cell alloantibodies anti-E, and anti-M, and anti-He were also present. Anti-E, present as an IgG antibody, crossed the placenta, but did not cause clinical problems in the E+ newborn, other than possible hyperbillirubinemia that was treated by phototherapy.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Jan 1 1995|
ASJC Scopus subject areas
- Immunology and Allergy