Case report: Phialophora verrucosa infection in a BMT patient

T. S. Lundstrom, M. R. Fairfax, M. C. Dugan, J. A. Vazquez, P. H. Chandrasekar, E. Abella, C. Kasten-Sportes

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Phialophora is a dematiaceous fungus isolated from soil and wood. Human infections including chromoblastomycosis, mycotic keratitis, cutaneous infections, and prosthetic valve endocarditis have been reported. We report a case of fatal hemorrhage due to Phialophora verrucosa in a patient with prolonged neutropenia undergoing autologous bone marrow transplant (BMT) for acute myelogenous leukemia (AML). Bacterial infections complicated induction and consolidation chemotherapies. Liposomal amphotericin B (LAMB) was given from day + 33 to day + 72 for febrile neutropenia. Death occurred on day + 74 due to tracheal hemorrhage. Autopsy revealed granulation tissue on the posterior wall of the trachea with fungal hyphae on histopathology; the tissue grew Phialophora verrucosa. In vitro susceptibility studies revealed a minimum inhibitory concentration to AmB of 0.1 μg/ml. This represents the first reported case of invasive P. verrucosa in a BMT patient leading to fatal hemorrhage, despite large cumulative doses of LAMB to which the organism remained susceptible.

Original languageEnglish (US)
Pages (from-to)789-791
Number of pages3
JournalBone marrow transplantation
Volume20
Issue number9
DOIs
StatePublished - Nov 1 1997

Fingerprint

Phialophora
Bone Marrow
Hemorrhage
Transplants
Infection
Chromoblastomycosis
Consolidation Chemotherapy
Febrile Neutropenia
Induction Chemotherapy
Granulation Tissue
Hyphae
Keratitis
Microbial Sensitivity Tests
Endocarditis
Trachea
Neutropenia
Bacterial Infections
Acute Myeloid Leukemia
Autopsy
Fungi

Keywords

  • Chromoblastomycoses
  • Fungus
  • Phialophora

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Lundstrom, T. S., Fairfax, M. R., Dugan, M. C., Vazquez, J. A., Chandrasekar, P. H., Abella, E., & Kasten-Sportes, C. (1997). Case report: Phialophora verrucosa infection in a BMT patient. Bone marrow transplantation, 20(9), 789-791. https://doi.org/10.1038/sj.bmt.1700969

Case report : Phialophora verrucosa infection in a BMT patient. / Lundstrom, T. S.; Fairfax, M. R.; Dugan, M. C.; Vazquez, J. A.; Chandrasekar, P. H.; Abella, E.; Kasten-Sportes, C.

In: Bone marrow transplantation, Vol. 20, No. 9, 01.11.1997, p. 789-791.

Research output: Contribution to journalArticle

Lundstrom, TS, Fairfax, MR, Dugan, MC, Vazquez, JA, Chandrasekar, PH, Abella, E & Kasten-Sportes, C 1997, 'Case report: Phialophora verrucosa infection in a BMT patient', Bone marrow transplantation, vol. 20, no. 9, pp. 789-791. https://doi.org/10.1038/sj.bmt.1700969
Lundstrom TS, Fairfax MR, Dugan MC, Vazquez JA, Chandrasekar PH, Abella E et al. Case report: Phialophora verrucosa infection in a BMT patient. Bone marrow transplantation. 1997 Nov 1;20(9):789-791. https://doi.org/10.1038/sj.bmt.1700969
Lundstrom, T. S. ; Fairfax, M. R. ; Dugan, M. C. ; Vazquez, J. A. ; Chandrasekar, P. H. ; Abella, E. ; Kasten-Sportes, C. / Case report : Phialophora verrucosa infection in a BMT patient. In: Bone marrow transplantation. 1997 ; Vol. 20, No. 9. pp. 789-791.
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