Ca2+, histamine antagonists and relaxation to electrical impulses in dog coronary artery

Robin D. Gantzos, Anthony B. Ebeigbe, R. Clinton Webb

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Isolated dog coronary arteries relax in response to electrical stimulation (0.1-8.0 Hz, 9 V, 1.0 ms) following contraction induced by serotonin. Cimetidine, metiamide and ranitidine inhibited this relaxation. The relaxation was not blocked by pyrilamine. Reducing the concentration of Ca+ (0.1 mM) decreased the rate of relaxation whereas relaxation was more rapid when the Ca2+ concentration was increased (3.2 mM). These results suggest that relaxation to electrical stimulation is modulated by Ca2+ and by the H2-subclass of histamine receptors.

Original languageEnglish (US)
Pages (from-to)287-291
Number of pages5
JournalEuropean Journal of Pharmacology
Volume89
Issue number3-4
DOIs
Publication statusPublished - May 6 1983
Externally publishedYes

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Keywords

  • Cimetidine
  • Coronary smooth muscle
  • Histamine
  • Metiamide
  • Pyrilamine
  • Ranitidine

ASJC Scopus subject areas

  • Pharmacology

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