Abstract
Isolated dog coronary arteries relax in response to electrical stimulation (0.1-8.0 Hz, 9 V, 1.0 ms) following contraction induced by serotonin. Cimetidine, metiamide and ranitidine inhibited this relaxation. The relaxation was not blocked by pyrilamine. Reducing the concentration of Ca+ (0.1 mM) decreased the rate of relaxation whereas relaxation was more rapid when the Ca2+ concentration was increased (3.2 mM). These results suggest that relaxation to electrical stimulation is modulated by Ca2+ and by the H2-subclass of histamine receptors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 287-291 |
| Number of pages | 5 |
| Journal | European Journal of Pharmacology |
| Volume | 89 |
| Issue number | 3-4 |
| DOIs | |
| State | Published - May 6 1983 |
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Keywords
- Cimetidine
- Coronary smooth muscle
- Histamine
- Metiamide
- Pyrilamine
- Ranitidine
ASJC Scopus subject areas
- Pharmacology
Cite this
Ca2+, histamine antagonists and relaxation to electrical impulses in dog coronary artery. / Gantzos, Robin D.; Ebeigbe, Anthony B.; Clinton Webb, R.
In: European Journal of Pharmacology, Vol. 89, No. 3-4, 06.05.1983, p. 287-291.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ca2+, histamine antagonists and relaxation to electrical impulses in dog coronary artery
AU - Gantzos, Robin D.
AU - Ebeigbe, Anthony B.
AU - Clinton Webb, R.
PY - 1983/5/6
Y1 - 1983/5/6
N2 - Isolated dog coronary arteries relax in response to electrical stimulation (0.1-8.0 Hz, 9 V, 1.0 ms) following contraction induced by serotonin. Cimetidine, metiamide and ranitidine inhibited this relaxation. The relaxation was not blocked by pyrilamine. Reducing the concentration of Ca+ (0.1 mM) decreased the rate of relaxation whereas relaxation was more rapid when the Ca2+ concentration was increased (3.2 mM). These results suggest that relaxation to electrical stimulation is modulated by Ca2+ and by the H2-subclass of histamine receptors.
AB - Isolated dog coronary arteries relax in response to electrical stimulation (0.1-8.0 Hz, 9 V, 1.0 ms) following contraction induced by serotonin. Cimetidine, metiamide and ranitidine inhibited this relaxation. The relaxation was not blocked by pyrilamine. Reducing the concentration of Ca+ (0.1 mM) decreased the rate of relaxation whereas relaxation was more rapid when the Ca2+ concentration was increased (3.2 mM). These results suggest that relaxation to electrical stimulation is modulated by Ca2+ and by the H2-subclass of histamine receptors.
KW - Cimetidine
KW - Coronary smooth muscle
KW - Histamine
KW - Metiamide
KW - Pyrilamine
KW - Ranitidine
UR - http://www.scopus.com/inward/record.url?scp=0020646499&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020646499&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(83)90508-3
DO - 10.1016/0014-2999(83)90508-3
M3 - Article
C2 - 6873165
AN - SCOPUS:0020646499
VL - 89
SP - 287
EP - 291
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 3-4
ER -