Ca2+, histamine antagonists and relaxation to electrical impulses in dog coronary artery

Robin D. Gantzos; Anthony B. Ebeigbe; R. Clinton Webb

doi:10.1016/0014-2999(83)90508-3

Ca²⁺, histamine antagonists and relaxation to electrical impulses in dog coronary artery

Robin D. Gantzos, Anthony B. Ebeigbe, R. Clinton Webb

Research output: Contribution to journal › Article

5 Scopus citations

Abstract

Isolated dog coronary arteries relax in response to electrical stimulation (0.1-8.0 Hz, 9 V, 1.0 ms) following contraction induced by serotonin. Cimetidine, metiamide and ranitidine inhibited this relaxation. The relaxation was not blocked by pyrilamine. Reducing the concentration of Ca⁺ (0.1 mM) decreased the rate of relaxation whereas relaxation was more rapid when the Ca²⁺ concentration was increased (3.2 mM). These results suggest that relaxation to electrical stimulation is modulated by Ca²⁺ and by the H₂-subclass of histamine receptors.

Original language	English (US)
Pages (from-to)	287-291
Number of pages	5
Journal	European Journal of Pharmacology
Volume	89
Issue number	3-4
DOIs	https://doi.org/10.1016/0014-2999(83)90508-3
Publication status	Published - May 6 1983
Externally published	Yes

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Keywords

Cimetidine
Coronary smooth muscle
Histamine
Metiamide
Pyrilamine
Ranitidine

ASJC Scopus subject areas

Pharmacology

Cite this

Gantzos, R. D., Ebeigbe, A. B., & Clinton Webb, R. (1983). Ca²⁺, histamine antagonists and relaxation to electrical impulses in dog coronary artery. European Journal of Pharmacology, 89(3-4), 287-291. https://doi.org/10.1016/0014-2999(83)90508-3

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AB - Isolated dog coronary arteries relax in response to electrical stimulation (0.1-8.0 Hz, 9 V, 1.0 ms) following contraction induced by serotonin. Cimetidine, metiamide and ranitidine inhibited this relaxation. The relaxation was not blocked by pyrilamine. Reducing the concentration of Ca+ (0.1 mM) decreased the rate of relaxation whereas relaxation was more rapid when the Ca2+ concentration was increased (3.2 mM). These results suggest that relaxation to electrical stimulation is modulated by Ca2+ and by the H2-subclass of histamine receptors.

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KW - Pyrilamine

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10.1016/0014-2999(83)90508-3