@article{a2724e689c5b408396725270dd03fd3a,
title = "Ca2+, histamine antagonists and relaxation to electrical impulses in dog coronary artery",
abstract = "Isolated dog coronary arteries relax in response to electrical stimulation (0.1-8.0 Hz, 9 V, 1.0 ms) following contraction induced by serotonin. Cimetidine, metiamide and ranitidine inhibited this relaxation. The relaxation was not blocked by pyrilamine. Reducing the concentration of Ca+ (0.1 mM) decreased the rate of relaxation whereas relaxation was more rapid when the Ca2+ concentration was increased (3.2 mM). These results suggest that relaxation to electrical stimulation is modulated by Ca2+ and by the H2-subclass of histamine receptors.",
keywords = "Cimetidine, Coronary smooth muscle, Histamine, Metiamide, Pyrilamine, Ranitidine",
author = "Gantzos, {Robin D.} and Ebeigbe, {Anthony B.} and {Clinton Webb}, R.",
note = "Funding Information: * Supported by grants from the National Institutes of Health (HL-27020, HL-18575). R.D.G. is the recipient of a Michi-gan Heart Association Student Fellowship. R.C.W. is the recipient of a Research Career Development Award from the National Institutes of Health (HL-00813). A.B.E. is an African Senior Research Scholar (Fulbright Award, Depart-ment of Physiology, University of Benin, Nigeria). ** To whom all correspondence should be addressed: Depart-ment of Physiology, University of Michigan, 7720 Medical Science Building II, Ann Arbor, Michigan 48109, U.S.A.",
year = "1983",
month = may,
day = "6",
doi = "10.1016/0014-2999(83)90508-3",
language = "English (US)",
volume = "89",
pages = "287--291",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "3-4",
}