Cavernous tissue antibiotic levels in penile prosthesis surgery

F. P. Walters, Durwood Earnest Neal, A. B. Rege, W. J. George, M. J. Ricci, W. J.G. Hellstrom

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A comparison of the delivery of several antibiotics (vancomycin, gentamicin and aztreonam) to the tissue site of prosthesis implantation was studied using cavernous tissue levels for each antibiotic. A total of 32 patients underwent penile prosthesis implantation. Intravenous antibiotics were administered 1 to 2 hours preoperatively, with vancomycin and aztreonam given to patients at the Tulane University Medical Center, and vancomycin and gentamicin given to patients at the New Orleans Veterans Administration Hospital. At operation the urine, serum and cavernous tissue were concurrently sampled and later analyzed for antibiotic concentration. The mean cavernous tissue level for vancomycin was 55.5 ± 5.5 ng./mg. (standard deviation) for 20 patients, while the mean cavernous tissue levels for aztreonam and gentamicin were 8.9 ± 2.1 ng./mg. for 10 patients and 4.7 ± 1.2 ng./mg. for 12 patients, respectively. When the delivery of antibiotic to cavernous tissue was compared (quantitated as ng. antibiotic per mg. tissue per mg. drug administered), a statistically significant value (p <0.01) was observed with vancomycin (0.11 ng./mg./mg.) greater than gentamicin (0.06 ng./mg./mg.) or aztreonam (0.01 ng./mg./mg.), and with no significant difference observed between aztreonam or gentamicin. These findings suggest that cavernous tissue levels may be used as a method to determine optimal antibiotic prophylaxis against penile prosthesis infection.

Original languageEnglish (US)
Pages (from-to)1282-1284
Number of pages3
JournalJournal of Urology
Volume147
Issue number5
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

Fingerprint

Penile Prosthesis
Aztreonam
Anti-Bacterial Agents
Vancomycin
Gentamicins
Penile Implantation
Prosthesis Implantation
Veterans Hospitals
United States Department of Veterans Affairs
Antibiotic Prophylaxis
Urine

Keywords

  • antibiotics
  • infection
  • penile prosthesis

ASJC Scopus subject areas

  • Urology

Cite this

Walters, F. P., Neal, D. E., Rege, A. B., George, W. J., Ricci, M. J., & Hellstrom, W. J. G. (1992). Cavernous tissue antibiotic levels in penile prosthesis surgery. Journal of Urology, 147(5), 1282-1284. https://doi.org/10.1016/S0022-5347(17)37543-2

Cavernous tissue antibiotic levels in penile prosthesis surgery. / Walters, F. P.; Neal, Durwood Earnest; Rege, A. B.; George, W. J.; Ricci, M. J.; Hellstrom, W. J.G.

In: Journal of Urology, Vol. 147, No. 5, 01.01.1992, p. 1282-1284.

Research output: Contribution to journalArticle

Walters, FP, Neal, DE, Rege, AB, George, WJ, Ricci, MJ & Hellstrom, WJG 1992, 'Cavernous tissue antibiotic levels in penile prosthesis surgery', Journal of Urology, vol. 147, no. 5, pp. 1282-1284. https://doi.org/10.1016/S0022-5347(17)37543-2
Walters FP, Neal DE, Rege AB, George WJ, Ricci MJ, Hellstrom WJG. Cavernous tissue antibiotic levels in penile prosthesis surgery. Journal of Urology. 1992 Jan 1;147(5):1282-1284. https://doi.org/10.1016/S0022-5347(17)37543-2
Walters, F. P. ; Neal, Durwood Earnest ; Rege, A. B. ; George, W. J. ; Ricci, M. J. ; Hellstrom, W. J.G. / Cavernous tissue antibiotic levels in penile prosthesis surgery. In: Journal of Urology. 1992 ; Vol. 147, No. 5. pp. 1282-1284.
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