CCR5 blockade modulates inflammation and alloimmunity in primates

Carsten Schröder, Richard N. Pierson, Bao Ngoc H. Nguyen, Douglas W. Kawka, Laurence B. Peterson, Guosheng Wu, Tianshu Zhang, Martin S. Springer, Sal J. Siciliano, Susan Iliff, Julia M. Ayala, Min Lu, John S. Mudgett, Kathy Lyons, Sander G. Mills, Geraldine G. Miller, Irwin I. Singer, Agnes M. Azimzadeh, Julie A. DeMartino

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

Pharmacologic antagonism of CCR5, a chemokine receptor expressed on macrophages and activated T cells, is an effective antiviral therapy in patients with macrophage-tropic HIV infection, but its efficacy in modulating inflammation and immunity is only just beginning to be investigated. In this regard, the recruitment of CCR5-bearing cells into clinical allografts is a hallmark of acute rejection and may anticipate chronic rejection, whereas conventionally immunosuppressed renal transplant patients homozygous for a nonfunctional Δ32 CCR5 receptor rarely exhibit late graft loss. Therefore, we explored the effects of a potent, highly selective CCR5 antagonist, Merck's compound 167 (CMPD 167), in an established cynomolgus monkey cardiac allograft model. Although perioperative stress responses (fever, diminished activity) and the recruitment of CCR5-bearing leukocytes into the graft were markedly attenuated, anti-CCR5 monotherapy only marginally prolonged allograft survival. In contrast, relative to cyclosporine A monotherapy, CMPD 167 with cyclosporine A delayed alloantibody production, suppressed cardiac allograft vasculopathy, and tended to further prolong graft survival. CCR5 therefore represents an attractive therapeutic target for attenuating postsurgical stress responses and favorably modulating pathogenic alloimmunity in primates, including man.

Original languageEnglish (US)
Pages (from-to)2289-2299
Number of pages11
JournalJournal of Immunology
Volume179
Issue number4
DOIs
StatePublished - Aug 15 2007

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Schröder, C., Pierson, R. N., Nguyen, B. N. H., Kawka, D. W., Peterson, L. B., Wu, G., Zhang, T., Springer, M. S., Siciliano, S. J., Iliff, S., Ayala, J. M., Lu, M., Mudgett, J. S., Lyons, K., Mills, S. G., Miller, G. G., Singer, I. I., Azimzadeh, A. M., & DeMartino, J. A. (2007). CCR5 blockade modulates inflammation and alloimmunity in primates. Journal of Immunology, 179(4), 2289-2299. https://doi.org/10.4049/jimmunol.179.4.2289