CD30 expression in acute lymphoblastic leukemia as assessed by flow cytometry analysis

Wenli Zheng, L. Jeffrey Medeiros, Ken H. Young, Maitrayee Goswami, Linda Powers, Hagop H. Kantarjian, Deborah A. Thomas, Jorge E. Cortes, Sa A. Wang

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

We assessed CD30 expression in patients with acute lymphoblastic leukemia (ALL) of either T-cell or B-cell lineage to examine the potential benefit of anti-CD30-targeted therapy in this group of patients. Bone marrow specimens of 34 patients with T- and 44 with B-ALL were assessed for CD30 expression by multicolor flow cytometry immunophenotyping analysis. Of these 78 patients, 75 (96%) were adults; and 63 (81%) had refractory/relapsed disease. Using an arbitrary 20% cut-off, 13/34 (38%) cases of T-ALL and 6/44 (13%) cases of B-ALL were considered to express CD30. In five patients with T-ALL with sequential bone marrow tested, increased CD30 expression was observed during the course of high-dose chemotherapy (p = 0.025). Philadelphia chromosome/BCR-ABL1 fusion was positive in 14/44 cases of B-ALL and 2/32 cases of T-ALL, which showed no significant correlation with CD30 expression. In summary, we detected CD30 expression in approximately one-third of patients with T-ALL, and less frequently in B-ALL (p = 0.017). In T-ALL, CD30 expression is up-regulated during high-dose chemotherapy. These data indicate that anti-CD30-targeted therapy may be a potential option for patients with T-ALL with refractory/relapsed disease.

Original languageEnglish (US)
Pages (from-to)624-627
Number of pages4
JournalLeukemia and Lymphoma
Volume55
Issue number3
DOIs
StatePublished - Mar 1 2014
Externally publishedYes

Keywords

  • Acute lymphoblastic leukemia
  • BCR-ABL1
  • CD30
  • Flow cytometry

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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  • Cite this

    Zheng, W., Medeiros, L. J., Young, K. H., Goswami, M., Powers, L., Kantarjian, H. H., Thomas, D. A., Cortes, J. E., & Wang, S. A. (2014). CD30 expression in acute lymphoblastic leukemia as assessed by flow cytometry analysis. Leukemia and Lymphoma, 55(3), 624-627. https://doi.org/10.3109/10428194.2013.820293