CD30 expression in high-risk acute myeloid Leukemia and myelodysplastic syndromes

Wenli Zheng, L. Jeffrey Medeiros, Ying Hu, Linda Powers, Jorge E. Cortes, Farhad Ravandi-Kashani, Hagop H. Kantarjian, Sa A. Wang

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Background: We assessed for CD30 expression in patients with acute myeloid leukemia (AML) or high-grade myelodysplastic syndrome (MDS) to examine the possibility that anti-CD30 could be targeted therapy in these patients. Methods: Multicolor flow cytometry immunophenotypic analysis was performed on bone marrow aspirates of 135 patients with AML or MDS and peripheral blood samples in a subset of 33 patients. Immunohistochemistry was performed on bone marrow aspirate clot specimens of 84 patients. Results: The median patient age was 63 years (range, 13-92 years); 102 (75%) patients had refractory or recurrent disease, and 68 (50%) had high-risk cytogenetics. Overall, the median percentage of blasts positive for CD30 was 14% (range, 0%-91%). By using an arbitrary 20% cutoff, 49 (36%) patients were considered to have CD30 expression. Monocytic cells, either mature or immature, were consistently negative for CD30. Therefore, CD30 expression was less in AML with monocytic differentiation (P =.006). The patients with persistent disease who had been actively treated had a higher level of CD30 expression than the patients who were untreated (P =.031). In paired samples, CD30 expression was consistently higher in bone marrow blasts than in peripheral blood blasts (P =.002). Immunohistochemistry demonstrated CD30 expression by myeloblasts in a subset of patients, but reactivity was generally weaker and focally compared. Conclusions: CD30 is expressed by myeloblasts in a substantial subset of patients with AML or MDS. Because the study group was composed mostly of patients with high-risk AML or MDS in whom very few treatment options are available, these data raise the possibility that anti-CD30-targeted therapy could be a potential option for this patient group.

Original languageEnglish (US)
Pages (from-to)307-314
Number of pages8
JournalClinical Lymphoma, Myeloma and Leukemia
Volume13
Issue number3
DOIs
StatePublished - Jun 2013

Keywords

  • Acute myeloid leukemia
  • CD30
  • Flow cytometry
  • Immunohistochemistry
  • Myelodysplastic syndromes

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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    Zheng, W., Medeiros, L. J., Hu, Y., Powers, L., Cortes, J. E., Ravandi-Kashani, F., Kantarjian, H. H., & Wang, S. A. (2013). CD30 expression in high-risk acute myeloid Leukemia and myelodysplastic syndromes. Clinical Lymphoma, Myeloma and Leukemia, 13(3), 307-314. https://doi.org/10.1016/j.clml.2012.12.006