CD34+/AC133+ endothelial progenitor cells as imaging probes for neovascularization of tumors

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

It was generally considered that blood vessel formation during postnatal life is restricted to angiogenesis only, and for decades tumor vascularization was thought to be the exclusive result of the sprouting of new vessels from the preexisting ones. However, recent studies demonstrated the existence of additional angiogenic and vasculogenic mechanisms associated with tumor growth. Tumor growth and metastasis strongly depends on neovascularization. Endothelial cells that contribute to tumor neovasculatures can originate from sprouting and co-option of neighboring pre-existing vessels. However, there is emerging evidence indicating that bone-marrow derived endothelial progenitor cells (EPCs) also contribute to the vasculogenesis and growth of certain tumors. A subpopulation of CD34+ human hematopoietic stem cells (HSCs) identified by the cell-surface molecule CD133 (AC133), have been shown to be more specific for endothelial differentiation and angiogenesis. We have published the reports showing involvement of peripheral blood, cord blood and bone marrow derived EPCs into tumor neovascularization, and the EPCs’ involvement in tumor neovascularization was determined by in vivo magnetic resonance and nuclear medicine imaging. In this communication different imaging modalities for in vivo tracking of EPCs to the sites of active angiogenesis/vasculogenesis are discussed, where EPCs are used as imaging probes.

Original languageEnglish (US)
Title of host publicationStem Cells and Cancer Stem Cells
Subtitle of host publicationTherapeutic Applications in Disease and Injury
PublisherSpringer Netherlands
Pages203-217
Number of pages15
Volume9
ISBN (Electronic)9789400756458
ISBN (Print)9789400756441
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Arbab, A. S. (2013). CD34+/AC133+ endothelial progenitor cells as imaging probes for neovascularization of tumors. In Stem Cells and Cancer Stem Cells: Therapeutic Applications in Disease and Injury (Vol. 9, pp. 203-217). Springer Netherlands. https://doi.org/10.1007/978-94-007-5645-8_20