CD4 + T cells pass through an effector phase during the process of in vivo tolerance induction

Ching Tai Huang, David L. Huso, Zhenbing Lu, Tianhong Wang, Gang Zhou, Eugene P. Kennedy, Charles G. Drake, David J. Morgan, Linda A. Sherman, Amy D. Higgins, Drew M. Pardoll, Adam J. Adler

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

An important process in the generation of tolerance to peripheral self-Ags is the induction of unresponsiveness in mature specific T cells. Although the end stage of this process, termed anergy, is well defined, the pathway by which naive T cells become anergic remains to be elucidated. Using an in vivo self-tolerance model, we demonstrate that CD4 + T cells pass through a significant effector stage on their way to an anergic state. This stage is characterized by production of effector cytokines, provision of help for CD8 + T cells, and induction of in vivo pathology within organs that express cognate Ag. These results suggest that the initial activation stage in T cell tolerance is similar to that seen in memory induction. They also suggest that autoimmune pathology can result during the natural process of tolerance induction rather than requiring that tolerance be broken.

Original languageEnglish (US)
Pages (from-to)3945-3953
Number of pages9
JournalJournal of Immunology
Volume170
Issue number8
DOIs
StatePublished - Apr 15 2003

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T-Lymphocytes
Pathology
Peripheral Tolerance
Self Tolerance
Cytokines

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

CD4 + T cells pass through an effector phase during the process of in vivo tolerance induction . / Huang, Ching Tai; Huso, David L.; Lu, Zhenbing; Wang, Tianhong; Zhou, Gang; Kennedy, Eugene P.; Drake, Charles G.; Morgan, David J.; Sherman, Linda A.; Higgins, Amy D.; Pardoll, Drew M.; Adler, Adam J.

In: Journal of Immunology, Vol. 170, No. 8, 15.04.2003, p. 3945-3953.

Research output: Contribution to journalArticle

Huang, CT, Huso, DL, Lu, Z, Wang, T, Zhou, G, Kennedy, EP, Drake, CG, Morgan, DJ, Sherman, LA, Higgins, AD, Pardoll, DM & Adler, AJ 2003, ' CD4 + T cells pass through an effector phase during the process of in vivo tolerance induction ', Journal of Immunology, vol. 170, no. 8, pp. 3945-3953. https://doi.org/10.4049/jimmunol.170.8.3945
Huang, Ching Tai ; Huso, David L. ; Lu, Zhenbing ; Wang, Tianhong ; Zhou, Gang ; Kennedy, Eugene P. ; Drake, Charles G. ; Morgan, David J. ; Sherman, Linda A. ; Higgins, Amy D. ; Pardoll, Drew M. ; Adler, Adam J. / CD4 + T cells pass through an effector phase during the process of in vivo tolerance induction In: Journal of Immunology. 2003 ; Vol. 170, No. 8. pp. 3945-3953.
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AU - Kennedy, Eugene P.

AU - Drake, Charles G.

AU - Morgan, David J.

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AU - Pardoll, Drew M.

AU - Adler, Adam J.

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