CD8 T cells and E-cadherin in host responses against oropharyngeal candidiasis

K. Quimby, E. A. Lilly, M. Zacharek, K. McNulty, J. E. Leigh, J. E. Vazquez, P. L. Fidel

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Background: Oropharyngeal candidiasis (OPC) is the most common oral infection in HIV + persons. Previous studies suggest a role for CD8 + T cells against OPC when CD4 + T cells are lost, but enhanced susceptibility to infection occurs when CD8 + T-cell migration is inhibited by reduced tissue E-cadherin. Objective: To conduct a longitudinal study of tissue CD8 + T-cells and E-cadherin expression before, during, and after the episodes of OPC. Methods: Oral fungal burden was monitored and tissue was evaluated for CD8 + T cells and E-cadherin over a 1-year period in HIV + persons with a history of, or an acute episode of, OPC. Results: While longitudinal analyses precluded formal interpretations, point prevalence analyses of the data set revealed that when patients experiencing OPC were successfully treated, tissue E-cadherin expression was similar to that in patients who had not experienced OPC, and higher numbers of CD8 + T cells were distributed throughout OPC - tissue under normal expression of E-cadherin. Conclusion: These results suggest that (1) reduction in tissue E-cadherin expression in patients with OPC + is not permanent, and (2) high numbers of CD8 + T cells can be distributed throughout OPC - tissue under normal E-cadherin expression. Together, these results extend our previous studies and continue to support a role for CD8 + T cells in host defense against OPC.

Original languageEnglish (US)
Pages (from-to)153-161
Number of pages9
JournalOral Diseases
Volume18
Issue number2
DOIs
Publication statusPublished - Mar 1 2012
Externally publishedYes

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Keywords

  • CD8 T cells
  • E-cadherin
  • HIV
  • Oropharyngeal candidiasis

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)

Cite this

Quimby, K., Lilly, E. A., Zacharek, M., McNulty, K., Leigh, J. E., Vazquez, J. E., & Fidel, P. L. (2012). CD8 T cells and E-cadherin in host responses against oropharyngeal candidiasis. Oral Diseases, 18(2), 153-161. https://doi.org/10.1111/j.1601-0825.2011.01856.x