Abstract
The amino-acid sequence of the precursor of the human tumour cell line-derived platelet-derived growth factor (PDGF) A-chain has been deduced from complementary DNA clones and the gene localized to chromosome 7. The protein shows extensive homology to the PDGF B-chain precursor. Expression of the PDGF A-chain gene is independent of that of the PDGF B-chain in a number of human tumour cell lines, and secretion of a PDGF-like growth factor of relative molecular mass 31,000 correlates with expression of A- but not B-chain messenger RNA.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 695-699 |
| Number of pages | 5 |
| Journal | Nature |
| Volume | 320 |
| Issue number | 6064 |
| DOIs | |
| State | Published - Dec 1 1986 |
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Cite this
cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines. / Betsholtz, C.; Johnsson, A.; Heldin, C. H.; Westermark, B.; Lind, P.; Urdea, M. S.; Eddy, R.; Shows, T. B.; Philpott, K.; Mellor, A. L.
In: Nature, Vol. 320, No. 6064, 01.12.1986, p. 695-699.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines
AU - Betsholtz, C.
AU - Johnsson, A.
AU - Heldin, C. H.
AU - Westermark, B.
AU - Lind, P.
AU - Urdea, M. S.
AU - Eddy, R.
AU - Shows, T. B.
AU - Philpott, K.
AU - Mellor, A. L.
PY - 1986/12/1
Y1 - 1986/12/1
N2 - The amino-acid sequence of the precursor of the human tumour cell line-derived platelet-derived growth factor (PDGF) A-chain has been deduced from complementary DNA clones and the gene localized to chromosome 7. The protein shows extensive homology to the PDGF B-chain precursor. Expression of the PDGF A-chain gene is independent of that of the PDGF B-chain in a number of human tumour cell lines, and secretion of a PDGF-like growth factor of relative molecular mass 31,000 correlates with expression of A- but not B-chain messenger RNA.
AB - The amino-acid sequence of the precursor of the human tumour cell line-derived platelet-derived growth factor (PDGF) A-chain has been deduced from complementary DNA clones and the gene localized to chromosome 7. The protein shows extensive homology to the PDGF B-chain precursor. Expression of the PDGF A-chain gene is independent of that of the PDGF B-chain in a number of human tumour cell lines, and secretion of a PDGF-like growth factor of relative molecular mass 31,000 correlates with expression of A- but not B-chain messenger RNA.
UR - http://www.scopus.com/inward/record.url?scp=0022447025&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022447025&partnerID=8YFLogxK
U2 - 10.1038/320695a0
DO - 10.1038/320695a0
M3 - Article
C2 - 3754619
AN - SCOPUS:0022447025
VL - 320
SP - 695
EP - 699
JO - Nature
JF - Nature
SN - 0028-0836
IS - 6064
ER -