Abstract
The amino-acid sequence of the precursor of the human tumour cell line-derived platelet-derived growth factor (PDGF) A-chain has been deduced from complementary DNA clones and the gene localized to chromosome 7. The protein shows extensive homology to the PDGF B-chain precursor. Expression of the PDGF A-chain gene is independent of that of the PDGF B-chain in a number of human tumour cell lines, and secretion of a PDGF-like growth factor of relative molecular mass 31,000 correlates with expression of A- but not B-chain messenger RNA.
Original language | English (US) |
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Pages (from-to) | 695-699 |
Number of pages | 5 |
Journal | Nature |
Volume | 320 |
Issue number | 6064 |
DOIs | |
State | Published - 1986 |
ASJC Scopus subject areas
- General