cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines

C. Betsholtz; A. Johnsson; C. H. Heldin; B. Westermark; P. Lind; M. S. Urdea; R. Eddy; T. B. Shows; K. Philpott; A. L. Mellor

doi:10.1038/320695a0

cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines

C. Betsholtz, A. Johnsson, C. H. Heldin, B. Westermark, P. Lind, M. S. Urdea, R. Eddy, T. B. Shows, K. Philpott, A. L. Mellor

Infectious Disease

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532 Scopus citations

Abstract

The amino-acid sequence of the precursor of the human tumour cell line-derived platelet-derived growth factor (PDGF) A-chain has been deduced from complementary DNA clones and the gene localized to chromosome 7. The protein shows extensive homology to the PDGF B-chain precursor. Expression of the PDGF A-chain gene is independent of that of the PDGF B-chain in a number of human tumour cell lines, and secretion of a PDGF-like growth factor of relative molecular mass 31,000 correlates with expression of A- but not B-chain messenger RNA.

Original language	English (US)
Pages (from-to)	695-699
Number of pages	5
Journal	Nature
Volume	320
Issue number	6064
DOIs	https://doi.org/10.1038/320695a0
State	Published - 1986

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cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines. / Betsholtz, C.; Johnsson, A.; Heldin, C. H.; Westermark, B.; Lind, P.; Urdea, M. S.; Eddy, R.; Shows, T. B.; Philpott, K.; Mellor, A. L.

In: Nature, Vol. 320, No. 6064, 1986, p. 695-699.

Research output: Contribution to journal › Article › peer-review

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AU - Betsholtz, C.

AU - Johnsson, A.

AU - Heldin, C. H.

AU - Westermark, B.

AU - Lind, P.

AU - Urdea, M. S.

AU - Eddy, R.

AU - Shows, T. B.

AU - Philpott, K.

AU - Mellor, A. L.

PY - 1986

Y1 - 1986

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AB - The amino-acid sequence of the precursor of the human tumour cell line-derived platelet-derived growth factor (PDGF) A-chain has been deduced from complementary DNA clones and the gene localized to chromosome 7. The protein shows extensive homology to the PDGF B-chain precursor. Expression of the PDGF A-chain gene is independent of that of the PDGF B-chain in a number of human tumour cell lines, and secretion of a PDGF-like growth factor of relative molecular mass 31,000 correlates with expression of A- but not B-chain messenger RNA.

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cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines

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