TY - JOUR
T1 - Cefaclor — A Cluster of Adverse Reactions
AU - Murray, Dennis L.
AU - Singer, Dale A.
AU - Singer, Alan B.
AU - Veldman, Jerold P.
PY - 1980/10/23
Y1 - 1980/10/23
N2 - To the Editor: Cefaclor (Ceclor, Eli Lilly, Indianapolis, Ind.) is an oral cephalosporin recently introduced for the treatment of otitis media in children. In one clinical trial, cefaclor has been found equal in efficacy to amoxicillin in acute bacterial otitis media.1 The drug is reported to be effective in vitro against some beta-lactamase-producing strains of Haemophilus influenzae, but not against all.2 Few adverse reactions to this antibiotic have been reported. In metropolitan Lansing, Michigan, from November 1979 through June 1980, a generalized pruritic rash and arthritis (swelling and pain in both knee and ankle joints) developed in eight children.
AB - To the Editor: Cefaclor (Ceclor, Eli Lilly, Indianapolis, Ind.) is an oral cephalosporin recently introduced for the treatment of otitis media in children. In one clinical trial, cefaclor has been found equal in efficacy to amoxicillin in acute bacterial otitis media.1 The drug is reported to be effective in vitro against some beta-lactamase-producing strains of Haemophilus influenzae, but not against all.2 Few adverse reactions to this antibiotic have been reported. In metropolitan Lansing, Michigan, from November 1979 through June 1980, a generalized pruritic rash and arthritis (swelling and pain in both knee and ankle joints) developed in eight children.
UR - http://www.scopus.com/inward/record.url?scp=0018943701&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018943701&partnerID=8YFLogxK
U2 - 10.1056/NEJM198010233031716
DO - 10.1056/NEJM198010233031716
M3 - Letter
C2 - 7412843
AN - SCOPUS:0018943701
SN - 0028-4793
VL - 303
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 17
ER -