Cefaclor — A Cluster of Adverse Reactions

Dennis L. Murray, Dale A. Singer, Alan B. Singer, Jerold P. Veldman

Research output: Contribution to journalLetter

35 Citations (Scopus)

Abstract

To the Editor: Cefaclor (Ceclor, Eli Lilly, Indianapolis, Ind.) is an oral cephalosporin recently introduced for the treatment of otitis media in children. In one clinical trial, cefaclor has been found equal in efficacy to amoxicillin in acute bacterial otitis media.1 The drug is reported to be effective in vitro against some beta-lactamase-producing strains of Haemophilus influenzae, but not against all.2 Few adverse reactions to this antibiotic have been reported. In metropolitan Lansing, Michigan, from November 1979 through June 1980, a generalized pruritic rash and arthritis (swelling and pain in both knee and ankle joints) developed in eight children.

Original languageEnglish (US)
Number of pages1
JournalNew England Journal of Medicine
Volume303
Issue number17
DOIs
StatePublished - Oct 23 1980

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Cefaclor
Otitis
Ankle Joint
Amoxicillin
Haemophilus influenzae
Otitis Media
Cephalosporins
beta-Lactamases
Knee Joint
Exanthema
Arthritis
Clinical Trials
Anti-Bacterial Agents
Pain
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Murray, D. L., Singer, D. A., Singer, A. B., & Veldman, J. P. (1980). Cefaclor — A Cluster of Adverse Reactions. New England Journal of Medicine, 303(17). https://doi.org/10.1056/NEJM198010233031716

Cefaclor — A Cluster of Adverse Reactions. / Murray, Dennis L.; Singer, Dale A.; Singer, Alan B.; Veldman, Jerold P.

In: New England Journal of Medicine, Vol. 303, No. 17, 23.10.1980.

Research output: Contribution to journalLetter

Murray, DL, Singer, DA, Singer, AB & Veldman, JP 1980, 'Cefaclor — A Cluster of Adverse Reactions', New England Journal of Medicine, vol. 303, no. 17. https://doi.org/10.1056/NEJM198010233031716
Murray, Dennis L. ; Singer, Dale A. ; Singer, Alan B. ; Veldman, Jerold P. / Cefaclor — A Cluster of Adverse Reactions. In: New England Journal of Medicine. 1980 ; Vol. 303, No. 17.
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