Cell type-specific and light-dependent expression of Rab1 and Rab6 GTPases in mammalian retinas

Wei Huang, Guangyu Wu, Guo Yong Wang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The Ras-like Rab1 and Rab6 GTPases modulate protein traffic along the ely secretory pathway and e involved in the regulation of maturation of rhodopsin in the outer retina. However, Rab GTPases have not been studied in the inner retinas. Here, we analyzed the anatomatic distribution and expression of Rab1 and Rab6 in the mouse and rat retinas by immunohistochemistry and immunoblotting. We found that Rab1 was specifically expressed in the rod bipol cells, while Rab6 was expressed in a different cell type(s) from rod bipol cells in the inner retina. We also demonstrated that expression of Rab1 and Rab6 was increased with light. These data provided the first evidence implicating that Rab1 and Rab6 may be involved in the regulation of the retinal adaptation.

Original languageEnglish (US)
Pages (from-to)443-452
Number of pages10
JournalVisual Neuroscience
Volume26
Issue number5-6
DOIs
StatePublished - Nov 1 2009

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GTP Phosphohydrolases
Retina
Light
rab GTP-Binding Proteins
Rhodopsin
Secretory Pathway
Immunoblotting
Immunohistochemistry
Proteins

Keywords

  • Inner nucle layer
  • Müller Cell
  • Protein kinase C
  • Retinal adaptation
  • Rod bipol cell

ASJC Scopus subject areas

  • Physiology
  • Sensory Systems

Cite this

Cell type-specific and light-dependent expression of Rab1 and Rab6 GTPases in mammalian retinas. / Huang, Wei; Wu, Guangyu; Wang, Guo Yong.

In: Visual Neuroscience, Vol. 26, No. 5-6, 01.11.2009, p. 443-452.

Research output: Contribution to journalArticle

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