Cellular adhesion and the endothelium: P-selectin

Abdullah Kutlar, Stephen H. Embury

Research output: Contribution to journalReview article

30 Scopus citations

Abstract

P-selectin on endothelial cell surfaces is central to impaired microvascular blood flow in sickle cell disease (SCD). Restoration of blood flow is expected to provide therapeutic benefit for SCD patients, whatever the mechanism of action of the treatment. Long-term oral administration of a P-selectin-blocking agent potentially improves blood flow and averts acute painful vaso-occlusive crises in patients with SCD. This review focuses on the pathophysiology of the impairment of microvascular blood flow in SCD with an emphasis on the role of P-selectin and summarizes the status of development of antiselectin therapies as a means of improving microvascular flow.

Original languageEnglish (US)
Pages (from-to)323-339
Number of pages17
JournalHematology/Oncology Clinics of North America
Volume28
Issue number2
DOIs
Publication statusPublished - Apr 1 2014

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Keywords

  • Impaired blood flow in sickle cell disease
  • Microvascular occlusion
  • P-selectin
  • Pentosan polysulfate sodium
  • Sickle cell disease
  • Sickle red cell adhesion

ASJC Scopus subject areas

  • Oncology
  • Hematology
  • Medicine(all)

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