Cellular connections, microenvironment and brain angiogenesis in diabetes: Lost communication signals in the post-stroke period

Adviye Ergul, John Paul Valenzuela, Abdelrahman Y. Fouda, Susan C. Fagan

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Diabetes not only increases the risk but also worsens the motor and cognitive recovery after stroke, which is the leading cause of disability worldwide. Repair after stroke requires coordinated communication among various cell types in the central nervous system as well as circulating cells. Vascular restoration is critical for the enhancement of neurogenesis and neuroplasticity. Given that vascular disease is a major component of all complications associated with diabetes including stroke, this review will focus on cellular communications that are important for vascular restoration in the context of diabetes. This article is part of a Special Issue entitled SI: Cell Interactions In Stroke.

Original languageEnglish (US)
Pages (from-to)81-96
Number of pages16
JournalBrain Research
Volume1623
DOIs
StatePublished - Oct 14 2015

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Keywords

  • Angiogenesis
  • Diabetes
  • Stroke
  • Vascular restoration

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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