Abstract
Postoperative adhesions are a significant source of morbidity, including contributions to pelvic pain, bowel obstruction, and infertility. While the mechanisms of postoperative adhesion development are complex and incompletely understood, hypoxia appears to trigger a cascade of intracellular responses involving hypoxia-inducible factors, lactate, reactive oxygen species, reactive nitrogen species, and insulin-like growth factors that results in manifestation of the adhesion phenotype. Thus, substantial evidence exists to implicate the direct role of cellular metabolism in wound repair and adhesion development.
Original language | English (US) |
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Pages (from-to) | 627-634 |
Number of pages | 8 |
Journal | Reproductive Sciences |
Volume | 16 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2009 |
Externally published | Yes |
Keywords
- Adhesions
- Apoptosis
- Hypoxia
- Hypoxia-inducible factor (HIF)
- Lactate
- Reactive oxygen species
ASJC Scopus subject areas
- Obstetrics and Gynecology