Cellular metabolism: Contribution to postoperative adhesion development

Valerie I. Shavell, Ghassan M. Saed, Michael P. Diamond

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Postoperative adhesions are a significant source of morbidity, including contributions to pelvic pain, bowel obstruction, and infertility. While the mechanisms of postoperative adhesion development are complex and incompletely understood, hypoxia appears to trigger a cascade of intracellular responses involving hypoxia-inducible factors, lactate, reactive oxygen species, reactive nitrogen species, and insulin-like growth factors that results in manifestation of the adhesion phenotype. Thus, substantial evidence exists to implicate the direct role of cellular metabolism in wound repair and adhesion development.

Original languageEnglish (US)
Pages (from-to)627-634
Number of pages8
JournalReproductive Sciences
Volume16
Issue number7
DOIs
StatePublished - Jul 1 2009

Fingerprint

Reactive Nitrogen Species
Pelvic Pain
Somatomedins
Infertility
Lactic Acid
Reactive Oxygen Species
Morbidity
Phenotype
Wounds and Injuries
Hypoxia

Keywords

  • Adhesions
  • Apoptosis
  • Hypoxia
  • Hypoxia-inducible factor (HIF)
  • Lactate
  • Reactive oxygen species

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Cellular metabolism : Contribution to postoperative adhesion development. / Shavell, Valerie I.; Saed, Ghassan M.; Diamond, Michael P.

In: Reproductive Sciences, Vol. 16, No. 7, 01.07.2009, p. 627-634.

Research output: Contribution to journalReview article

Shavell, Valerie I. ; Saed, Ghassan M. ; Diamond, Michael P. / Cellular metabolism : Contribution to postoperative adhesion development. In: Reproductive Sciences. 2009 ; Vol. 16, No. 7. pp. 627-634.
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