Central 6-hydroxydopamine and renal sodium retention in mineralocorticoid-treated rats

J. L. Hall, T. E. Mecca, R. L. Malvin, R Clinton Webb

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Abstract

Cerebroventricular administration of 6-hydroxydopamine attenuated the development of deoxycorticosterone hypertension in the rat but did not affect the inital period of renal sodium retention. However, escape from the sodium retention was greater in 6-hydroxydopamine-treated rats. These data support the hypothesis that destruction of central catecholamine-containing neurons influences the renal handling of sodium. The enhanced escape may lead to diminished total body sodium, which attenuates the development of deoxycorticosterone hypertension.

Original languageEnglish (US)
Pages (from-to)1572-1575
Number of pages4
JournalCanadian Journal of Physiology and Pharmacology
Volume64
Issue number12
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

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ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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