Central Anticholinergic Hypersensitivity in Aging

P. G. Ray, K. J. Meador, D. W. Loring, E. W. Zamrini, X. H. Yang, J. J. Buccafusco

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Although neurochemical reductions in cholinergic systems have been found to occur during aging, such changes do not necessarily translate to functional deficits. The cognitive deficits of normal aging have been attributed in part to hypo-cholinergic function, but anticholinergic hypersensitivity in the elderly has not been systematically documented. To test the cholinergic hypothesis of aging, we investigated the effects of scopolamine on memory and attention in healthy young and elderly subjects. Treatments included intramuscular glycopyrrolate (0.0044 mg/kg) and scopolamine (0.002, 0.004, and 0.007 mg/kg) in a randomized double-blind design. The test battery included the Selective Reminding Task (SRT), Digit Span, Paired Associates Learning (PAL), Symbol Digit Modalities Test (SDMT), and the Continuous Performance Task. Elderly controls were more impaired at lower scopolamine doses than were the young on SRT, PAL, and SDMT. These results demonstrate anticholinergic hypersensitivity and are consistent with decremental changes in cholinergic status during normal aging. (J Geriatr Psychiatry Neurol 1992;5:72–77).

Original languageEnglish (US)
Pages (from-to)72-77
Number of pages6
JournalJournal of Geriatric Psychiatry and Neurology
Volume5
Issue number2
DOIs
StatePublished - Jan 1 1992

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Cholinergic Antagonists
Cholinergic Agents
Scopolamine Hydrobromide
Hypersensitivity
Paired-Associate Learning
Glycopyrrolate
Task Performance and Analysis
Psychiatry
Therapeutics

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Ray, P. G., Meador, K. J., Loring, D. W., Zamrini, E. W., Yang, X. H., & Buccafusco, J. J. (1992). Central Anticholinergic Hypersensitivity in Aging. Journal of Geriatric Psychiatry and Neurology, 5(2), 72-77. https://doi.org/10.1177/002383099200500203

Central Anticholinergic Hypersensitivity in Aging. / Ray, P. G.; Meador, K. J.; Loring, D. W.; Zamrini, E. W.; Yang, X. H.; Buccafusco, J. J.

In: Journal of Geriatric Psychiatry and Neurology, Vol. 5, No. 2, 01.01.1992, p. 72-77.

Research output: Contribution to journalArticle

Ray, PG, Meador, KJ, Loring, DW, Zamrini, EW, Yang, XH & Buccafusco, JJ 1992, 'Central Anticholinergic Hypersensitivity in Aging', Journal of Geriatric Psychiatry and Neurology, vol. 5, no. 2, pp. 72-77. https://doi.org/10.1177/002383099200500203
Ray PG, Meador KJ, Loring DW, Zamrini EW, Yang XH, Buccafusco JJ. Central Anticholinergic Hypersensitivity in Aging. Journal of Geriatric Psychiatry and Neurology. 1992 Jan 1;5(2):72-77. https://doi.org/10.1177/002383099200500203
Ray, P. G. ; Meador, K. J. ; Loring, D. W. ; Zamrini, E. W. ; Yang, X. H. ; Buccafusco, J. J. / Central Anticholinergic Hypersensitivity in Aging. In: Journal of Geriatric Psychiatry and Neurology. 1992 ; Vol. 5, No. 2. pp. 72-77.
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