Central nervous system effects of leptin

Clint Buchanan, Virendra Mahesh, Pedro Zamorano, Darrell W Brann

Research output: Contribution to journalReview article

23 Citations (Scopus)

Abstract

Evidence exists demonstrating the importance of leptin in the control of energy homeostasis, feeding behavior and reproductive function. Leptin receptors are localized in several regions of the brain implicated in regulation of energy balance and reproductive function, including the arcuate nucleus/median eminence, paraventricular nucleus, and ventromedial nucleus. Administration of exogenous leptin has been shown to alter function of the hypothalamic-pituitary-adrenal axis and stimulate gonadotropin release through hypothalamic and pituitary actions. Results from in situ hybridization studies demonstrate the ability of leptin to modulate the expression of key neuropeptides (neuropeptide Y, corticotropin-releasing hormone) implicated in the regulation of energy homeostasis. This suggests that leptin is an important component in the neuroendocrine transmission line that regulates appetite, energy balance and reproduction.

Original languageEnglish (US)
Pages (from-to)146-150
Number of pages5
JournalTrends in Endocrinology and Metabolism
Volume9
Issue number4
DOIs
StatePublished - Dec 1 1998

Fingerprint

Leptin
Central Nervous System
Homeostasis
Leptin Receptors
Median Eminence
Arcuate Nucleus of Hypothalamus
Aptitude
Paraventricular Hypothalamic Nucleus
Neuropeptide Y
Corticotropin-Releasing Hormone
Feeding Behavior
Appetite
Neuropeptides
Gonadotropins
In Situ Hybridization
Reproduction
Brain

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Central nervous system effects of leptin. / Buchanan, Clint; Mahesh, Virendra; Zamorano, Pedro; Brann, Darrell W.

In: Trends in Endocrinology and Metabolism, Vol. 9, No. 4, 01.12.1998, p. 146-150.

Research output: Contribution to journalReview article

Buchanan, Clint ; Mahesh, Virendra ; Zamorano, Pedro ; Brann, Darrell W. / Central nervous system effects of leptin. In: Trends in Endocrinology and Metabolism. 1998 ; Vol. 9, No. 4. pp. 146-150.
@article{5a076deaae4b4c619be9e0b0f1bae95b,
title = "Central nervous system effects of leptin",
abstract = "Evidence exists demonstrating the importance of leptin in the control of energy homeostasis, feeding behavior and reproductive function. Leptin receptors are localized in several regions of the brain implicated in regulation of energy balance and reproductive function, including the arcuate nucleus/median eminence, paraventricular nucleus, and ventromedial nucleus. Administration of exogenous leptin has been shown to alter function of the hypothalamic-pituitary-adrenal axis and stimulate gonadotropin release through hypothalamic and pituitary actions. Results from in situ hybridization studies demonstrate the ability of leptin to modulate the expression of key neuropeptides (neuropeptide Y, corticotropin-releasing hormone) implicated in the regulation of energy homeostasis. This suggests that leptin is an important component in the neuroendocrine transmission line that regulates appetite, energy balance and reproduction.",
author = "Clint Buchanan and Virendra Mahesh and Pedro Zamorano and Brann, {Darrell W}",
year = "1998",
month = "12",
day = "1",
doi = "10.1016/S1043-2760(98)00038-1",
language = "English (US)",
volume = "9",
pages = "146--150",
journal = "Trends in Endocrinology and Metabolism",
issn = "1043-2760",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Central nervous system effects of leptin

AU - Buchanan, Clint

AU - Mahesh, Virendra

AU - Zamorano, Pedro

AU - Brann, Darrell W

PY - 1998/12/1

Y1 - 1998/12/1

N2 - Evidence exists demonstrating the importance of leptin in the control of energy homeostasis, feeding behavior and reproductive function. Leptin receptors are localized in several regions of the brain implicated in regulation of energy balance and reproductive function, including the arcuate nucleus/median eminence, paraventricular nucleus, and ventromedial nucleus. Administration of exogenous leptin has been shown to alter function of the hypothalamic-pituitary-adrenal axis and stimulate gonadotropin release through hypothalamic and pituitary actions. Results from in situ hybridization studies demonstrate the ability of leptin to modulate the expression of key neuropeptides (neuropeptide Y, corticotropin-releasing hormone) implicated in the regulation of energy homeostasis. This suggests that leptin is an important component in the neuroendocrine transmission line that regulates appetite, energy balance and reproduction.

AB - Evidence exists demonstrating the importance of leptin in the control of energy homeostasis, feeding behavior and reproductive function. Leptin receptors are localized in several regions of the brain implicated in regulation of energy balance and reproductive function, including the arcuate nucleus/median eminence, paraventricular nucleus, and ventromedial nucleus. Administration of exogenous leptin has been shown to alter function of the hypothalamic-pituitary-adrenal axis and stimulate gonadotropin release through hypothalamic and pituitary actions. Results from in situ hybridization studies demonstrate the ability of leptin to modulate the expression of key neuropeptides (neuropeptide Y, corticotropin-releasing hormone) implicated in the regulation of energy homeostasis. This suggests that leptin is an important component in the neuroendocrine transmission line that regulates appetite, energy balance and reproduction.

UR - http://www.scopus.com/inward/record.url?scp=0031800341&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031800341&partnerID=8YFLogxK

U2 - 10.1016/S1043-2760(98)00038-1

DO - 10.1016/S1043-2760(98)00038-1

M3 - Review article

VL - 9

SP - 146

EP - 150

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

SN - 1043-2760

IS - 4

ER -