TY - JOUR
T1 - Central nervous system effects of leptin
AU - Buchanan, Clint
AU - Mahesh, Virendra
AU - Zamorano, Pedro
AU - Brann, Darrell
PY - 1998/12/1
Y1 - 1998/12/1
N2 - Evidence exists demonstrating the importance of leptin in the control of energy homeostasis, feeding behavior and reproductive function. Leptin receptors are localized in several regions of the brain implicated in regulation of energy balance and reproductive function, including the arcuate nucleus/median eminence, paraventricular nucleus, and ventromedial nucleus. Administration of exogenous leptin has been shown to alter function of the hypothalamic-pituitary-adrenal axis and stimulate gonadotropin release through hypothalamic and pituitary actions. Results from in situ hybridization studies demonstrate the ability of leptin to modulate the expression of key neuropeptides (neuropeptide Y, corticotropin-releasing hormone) implicated in the regulation of energy homeostasis. This suggests that leptin is an important component in the neuroendocrine transmission line that regulates appetite, energy balance and reproduction.
AB - Evidence exists demonstrating the importance of leptin in the control of energy homeostasis, feeding behavior and reproductive function. Leptin receptors are localized in several regions of the brain implicated in regulation of energy balance and reproductive function, including the arcuate nucleus/median eminence, paraventricular nucleus, and ventromedial nucleus. Administration of exogenous leptin has been shown to alter function of the hypothalamic-pituitary-adrenal axis and stimulate gonadotropin release through hypothalamic and pituitary actions. Results from in situ hybridization studies demonstrate the ability of leptin to modulate the expression of key neuropeptides (neuropeptide Y, corticotropin-releasing hormone) implicated in the regulation of energy homeostasis. This suggests that leptin is an important component in the neuroendocrine transmission line that regulates appetite, energy balance and reproduction.
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U2 - 10.1016/S1043-2760(98)00038-1
DO - 10.1016/S1043-2760(98)00038-1
M3 - Review article
C2 - 18406258
AN - SCOPUS:0031800341
SN - 1043-2760
VL - 9
SP - 146
EP - 150
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 4
ER -