TY - JOUR
T1 - Centrosome hypertrophy in human breast tumors
T2 - Implications for genomic stability and cell polarity
AU - Lingle, Wilma L.
AU - Lutz, Ward H.
AU - Ingle, James N.
AU - Maihle, Nita J.
AU - Salisbury, Jeffrey L.
PY - 1998/3/17
Y1 - 1998/3/17
N2 - The centrosome plays an important role in maintenance of cell polarity and in progression through the cell cycle by determining the number, polarity, and organization of interphase and mitotic microtubules. By examining a set of 35 high grade human breast tumors, we show that centrosomes of adenocarcinoma cells generally display abnormal structure, aberrant protein phosphorylation, and increased microtubule nucleating capacity in comparison to centrosomes of normal breast epithelial and stromal tissues. These structural and functional centrosome defects have important implications for understanding the mechanisms by which genomic instability and loss of cell polarity develop in solid tumors.
AB - The centrosome plays an important role in maintenance of cell polarity and in progression through the cell cycle by determining the number, polarity, and organization of interphase and mitotic microtubules. By examining a set of 35 high grade human breast tumors, we show that centrosomes of adenocarcinoma cells generally display abnormal structure, aberrant protein phosphorylation, and increased microtubule nucleating capacity in comparison to centrosomes of normal breast epithelial and stromal tissues. These structural and functional centrosome defects have important implications for understanding the mechanisms by which genomic instability and loss of cell polarity develop in solid tumors.
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U2 - 10.1073/pnas.95.6.2950
DO - 10.1073/pnas.95.6.2950
M3 - Article
C2 - 9501196
AN - SCOPUS:0032539868
SN - 0027-8424
VL - 95
SP - 2950
EP - 2955
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 6
ER -