Centrosome hypertrophy in human breast tumors: Implications for genomic stability and cell polarity

Wilma L. Lingle, Ward H. Lutz, James N. Ingle, Nita J. Maihle, Jeffrey L. Salisbury

Research output: Contribution to journalArticle

398 Citations (Scopus)

Abstract

The centrosome plays an important role in maintenance of cell polarity and in progression through the cell cycle by determining the number, polarity, and organization of interphase and mitotic microtubules. By examining a set of 35 high grade human breast tumors, we show that centrosomes of adenocarcinoma cells generally display abnormal structure, aberrant protein phosphorylation, and increased microtubule nucleating capacity in comparison to centrosomes of normal breast epithelial and stromal tissues. These structural and functional centrosome defects have important implications for understanding the mechanisms by which genomic instability and loss of cell polarity develop in solid tumors.

Original languageEnglish (US)
Pages (from-to)2950-2955
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume95
Issue number6
DOIs
StatePublished - Mar 17 1998

Fingerprint

Cell Polarity
Centrosome
Genomic Instability
Hypertrophy
Breast Neoplasms
Microtubules
Interphase
Cell Cycle
Adenocarcinoma
Breast
Epithelium
Maintenance
Phosphorylation
Neoplasms
Proteins

ASJC Scopus subject areas

  • General

Cite this

Centrosome hypertrophy in human breast tumors : Implications for genomic stability and cell polarity. / Lingle, Wilma L.; Lutz, Ward H.; Ingle, James N.; Maihle, Nita J.; Salisbury, Jeffrey L.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, No. 6, 17.03.1998, p. 2950-2955.

Research output: Contribution to journalArticle

Lingle, Wilma L. ; Lutz, Ward H. ; Ingle, James N. ; Maihle, Nita J. ; Salisbury, Jeffrey L. / Centrosome hypertrophy in human breast tumors : Implications for genomic stability and cell polarity. In: Proceedings of the National Academy of Sciences of the United States of America. 1998 ; Vol. 95, No. 6. pp. 2950-2955.
@article{d305ee533b4c4860b8b7293b9bae4c28,
title = "Centrosome hypertrophy in human breast tumors: Implications for genomic stability and cell polarity",
abstract = "The centrosome plays an important role in maintenance of cell polarity and in progression through the cell cycle by determining the number, polarity, and organization of interphase and mitotic microtubules. By examining a set of 35 high grade human breast tumors, we show that centrosomes of adenocarcinoma cells generally display abnormal structure, aberrant protein phosphorylation, and increased microtubule nucleating capacity in comparison to centrosomes of normal breast epithelial and stromal tissues. These structural and functional centrosome defects have important implications for understanding the mechanisms by which genomic instability and loss of cell polarity develop in solid tumors.",
author = "Lingle, {Wilma L.} and Lutz, {Ward H.} and Ingle, {James N.} and Maihle, {Nita J.} and Salisbury, {Jeffrey L.}",
year = "1998",
month = "3",
day = "17",
doi = "10.1073/pnas.95.6.2950",
language = "English (US)",
volume = "95",
pages = "2950--2955",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "6",

}

TY - JOUR

T1 - Centrosome hypertrophy in human breast tumors

T2 - Implications for genomic stability and cell polarity

AU - Lingle, Wilma L.

AU - Lutz, Ward H.

AU - Ingle, James N.

AU - Maihle, Nita J.

AU - Salisbury, Jeffrey L.

PY - 1998/3/17

Y1 - 1998/3/17

N2 - The centrosome plays an important role in maintenance of cell polarity and in progression through the cell cycle by determining the number, polarity, and organization of interphase and mitotic microtubules. By examining a set of 35 high grade human breast tumors, we show that centrosomes of adenocarcinoma cells generally display abnormal structure, aberrant protein phosphorylation, and increased microtubule nucleating capacity in comparison to centrosomes of normal breast epithelial and stromal tissues. These structural and functional centrosome defects have important implications for understanding the mechanisms by which genomic instability and loss of cell polarity develop in solid tumors.

AB - The centrosome plays an important role in maintenance of cell polarity and in progression through the cell cycle by determining the number, polarity, and organization of interphase and mitotic microtubules. By examining a set of 35 high grade human breast tumors, we show that centrosomes of adenocarcinoma cells generally display abnormal structure, aberrant protein phosphorylation, and increased microtubule nucleating capacity in comparison to centrosomes of normal breast epithelial and stromal tissues. These structural and functional centrosome defects have important implications for understanding the mechanisms by which genomic instability and loss of cell polarity develop in solid tumors.

UR - http://www.scopus.com/inward/record.url?scp=0032539868&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032539868&partnerID=8YFLogxK

U2 - 10.1073/pnas.95.6.2950

DO - 10.1073/pnas.95.6.2950

M3 - Article

C2 - 9501196

AN - SCOPUS:0032539868

VL - 95

SP - 2950

EP - 2955

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 6

ER -