@inbook{1760489f24b34acbbd551a7d5324512f,
title = "Ceramide and S1P signaling in embryonic stem cell differentiation",
abstract = "Bioactive sphingolipids are important regulators for stem cell survival and differentiation. Most recently, we have coined the term “morphogenetic lipids” for sphingolipids that regulate stem cells during embryonic and postnatal development. The sphingolipid ceramide and its derivative, sphingosine-1-phosphate (S1P), can act synergistically as well as antagonistically on embryonic stem (ES) cell differentiation. We show here simple as well as state-of-the-art methods to analyze sphingolipids in differentiating ES cells and discuss new protocols to use ceramide and S1P analogs for the guided differentiation of mouse ES cells toward neuronal and glial lineage.",
keywords = "Apoptosis, Ceramide, Neuroprogenitor, Oligodendrocyte precursor, Sphingolipid, Sphingosine-1-phosphate, Teratoma",
author = "Guanghu Wang and Spassieva, {Stefka D.} and Erhard Bieberich",
note = "Publisher Copyright: {\textcopyright} 2017, Springer Science+Business Media New York.",
year = "2018",
doi = "10.1007/7651_2017_43",
language = "English (US)",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "153--171",
booktitle = "Methods in Molecular Biology",
}