Ceramide and sphingosine-1-phosphate signaling in embryonic stem cell differentiation

Erhard Bieberich

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations

Abstract

Recent studies show that bioactive lipids are important regulators for stem cell survival and differentiation. The sphingolipid ceramide and its derivative, sphingosine-1-phosphate (S1P), can act synergistically on embryonic stem (ES) cell differentiation. We show here simple methods to analyze sphingolipids in differentiating ES cells and to use ceramide and S1P analogs for the guided differentiation of mouse ES cells toward neuronal and glial lineage.

Original languageEnglish (US)
Title of host publicationSphingosine-1-Phosphate
Subtitle of host publicationMethods and Protocols
EditorsAlice Pebay, Kursad Turksen
Pages177-192
Number of pages16
DOIs
StatePublished - 2012

Publication series

NameMethods in Molecular Biology
Volume874
ISSN (Print)1064-3745

Keywords

  • Apoptosis
  • Ceramide
  • Neuroprogenitor
  • Oligodendrocyte precursor
  • Sphingolipid
  • Sphingosine-1-phosphate
  • Teratoma

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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  • Cite this

    Bieberich, E. (2012). Ceramide and sphingosine-1-phosphate signaling in embryonic stem cell differentiation. In A. Pebay, & K. Turksen (Eds.), Sphingosine-1-Phosphate: Methods and Protocols (pp. 177-192). (Methods in Molecular Biology; Vol. 874). https://doi.org/10.1007/978-1-61779-800-9_14