Ceramide and sphingosine-1-phosphate signaling in embryonic stem cell differentiation

Erhard Bieberich

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Citations (Scopus)

Abstract

Recent studies show that bioactive lipids are important regulators for stem cell survival and differentiation. The sphingolipid ceramide and its derivative, sphingosine-1-phosphate (S1P), can act synergistically on embryonic stem (ES) cell differentiation. We show here simple methods to analyze sphingolipids in differentiating ES cells and to use ceramide and S1P analogs for the guided differentiation of mouse ES cells toward neuronal and glial lineage.

Original languageEnglish (US)
Title of host publicationSphingosine-1-Phosphate
Subtitle of host publicationMethods and Protocols
EditorsAlice Pebay, Kursad Turksen
Pages177-192
Number of pages16
DOIs
StatePublished - May 8 2012

Publication series

NameMethods in Molecular Biology
Volume874
ISSN (Print)1064-3745

Fingerprint

Sphingolipids
Embryonic Stem Cells
Cell Differentiation
Ceramides
Neuroglia
Cell Survival
Stem Cells
Lipids
sphingosine 1-phosphate
ceramide 1-phosphate
Mouse Embryonic Stem Cells

Keywords

  • Apoptosis
  • Ceramide
  • Neuroprogenitor
  • Oligodendrocyte precursor
  • Sphingolipid
  • Sphingosine-1-phosphate
  • Teratoma

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Bieberich, E. (2012). Ceramide and sphingosine-1-phosphate signaling in embryonic stem cell differentiation. In A. Pebay, & K. Turksen (Eds.), Sphingosine-1-Phosphate: Methods and Protocols (pp. 177-192). (Methods in Molecular Biology; Vol. 874). https://doi.org/10.1007/978-1-61779-800-9_14

Ceramide and sphingosine-1-phosphate signaling in embryonic stem cell differentiation. / Bieberich, Erhard.

Sphingosine-1-Phosphate: Methods and Protocols. ed. / Alice Pebay; Kursad Turksen. 2012. p. 177-192 (Methods in Molecular Biology; Vol. 874).

Research output: Chapter in Book/Report/Conference proceedingChapter

Bieberich, E 2012, Ceramide and sphingosine-1-phosphate signaling in embryonic stem cell differentiation. in A Pebay & K Turksen (eds), Sphingosine-1-Phosphate: Methods and Protocols. Methods in Molecular Biology, vol. 874, pp. 177-192. https://doi.org/10.1007/978-1-61779-800-9_14
Bieberich E. Ceramide and sphingosine-1-phosphate signaling in embryonic stem cell differentiation. In Pebay A, Turksen K, editors, Sphingosine-1-Phosphate: Methods and Protocols. 2012. p. 177-192. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-61779-800-9_14
Bieberich, Erhard. / Ceramide and sphingosine-1-phosphate signaling in embryonic stem cell differentiation. Sphingosine-1-Phosphate: Methods and Protocols. editor / Alice Pebay ; Kursad Turksen. 2012. pp. 177-192 (Methods in Molecular Biology).
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