Ceramide induces apoptosis via a peroxisome proliferator-activated receptor γ-dependent pathway

Jing Wang, Xiaowen Lv, Jieping Shi, Xiaosong Hu

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Both of ceramide and PPARγ ligand can trigger cancer cell apoptosis. We here show that C2-ceramide can modulate PPARγ expression level and its transcriptional activity and results in apoptosis in HT29 cells. Administration of PPARγ specific antagonist GW9662 partially prevents HT29 cells from apoptosis. Furthermore, MAP kinase pathway provided a potential modulation mechanism for PPARγ pathway related with ceramide. Our results are the first to demonstrate that C2-ceramide induces apoptosis via a PPARγ-dependent pathway.

Original languageEnglish (US)
Pages (from-to)2043-2052
Number of pages10
JournalApoptosis
Volume11
Issue number11
DOIs
Publication statusPublished - Nov 1 2006
Externally publishedYes

    Fingerprint

Keywords

  • Apoptosis
  • Ceramide
  • MAPK
  • PPARγ
  • Troglitazone

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Cancer Research

Cite this