Mozgovoi krovotok moduliruet neirotoksicheskoe deistvie giperbaricheskogo kisloroda s pomoshch'iu neironal'nogo i endotelial'nogo oksida azota.

Translated title of the contribution: Cerebral blood flow modulates hyperbaric oxygen induced neurotoxicity by neuronal and endothelial nitric oxide

A. N. Moskvin, S. I. Zhiliaev, O. I. Sharapov, T. F. Platonova, Diana Raisovna Gutsaeva, V. B. Kostkin, I. T. Demchenko

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The goal of work was to reveal changes in microcirculation of the rat brain and the role of nitric oxide (NO) in development of seizures at hyperbaric oxygen exposure. The Wistar rats with implanted paired platinum electrodes in left and right striatum were used for experiments. The latency of seizures was defined by the EEG, the cerebral blood flow (CBF) was measured by hydrogen clearance. One group of animals was exposed to a 5-ata oxygen, while the others before oxygen treatment were injected with: Nw-nitro-L-arginine methyl ester (L-NAME), blockator of constitutive NO synthase; 7-nitroindozol (7NI), specific inhibitor of neural NO synthase. The latency of seizures was 41 +/- 1.9 min at 5 ata oxygen exposure. CBF was decreased to 10-14% but before seizures it increased to 23 +/- 9%. L-NAME and 7NI prevented development of hyperoxygen hyperemia and onset of seizures. The results indicate occurrence of hyperbaric oxygen changes of the CBF that modulate neurotoxic effects of NO in neurons as well as in cerebral vessels.

Original languageRussian
Pages (from-to)873-880
Number of pages8
JournalRossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk
Volume88
Issue number7
StatePublished - Jan 1 2002
Externally publishedYes

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Cerebrovascular Circulation
Nitric Oxide
Seizures
Oxygen
NG-Nitroarginine Methyl Ester
Nitric Oxide Synthase
Hyperemia
Microcirculation
Platinum
Wistar Rats
Electroencephalography
Hydrogen
Electrodes
Neurons
Brain

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mozgovoi krovotok moduliruet neirotoksicheskoe deistvie giperbaricheskogo kisloroda s pomoshch'iu neironal'nogo i endotelial'nogo oksida azota. / Moskvin, A. N.; Zhiliaev, S. I.; Sharapov, O. I.; Platonova, T. F.; Gutsaeva, Diana Raisovna; Kostkin, V. B.; Demchenko, I. T.

In: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk, Vol. 88, No. 7, 01.01.2002, p. 873-880.

Research output: Contribution to journalArticle

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