Cerebrovascular complications of alcohol and sympathomimetic drug abuse

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

Alcohol abuse has been linked to intracranial hemorrhage, both intracerebral and subarachnoid. Some studies have found a dose-response relationship, so that increasing levels of abuse are associated with greater risk of hemorrhage. However, alcohol abuse has not been clearly linked to cerebral infarction, and some studies find that mild-to-moderate drinking appears to be associated with a decreased risk of cerebral infarction. Intravenous administration of drugs of abuse predisposes to endocarditis, which may lead to embolic stroke. Associations have been reported between various sympathomimetic drugs and cerebral infarction. A possible mechanism for cerebral infarction is focal arterial vasoconstriction and occasionally cerebral vasculitis. Associations have also been reported between various sympathomimetic drugs and intracranial hemorrhage. A likely mechanism for intracranial hemorrhage is acute arterial hypertension. With the exception of endocarditis, management of stroke related to drug abuse is largely supportive, with emphasis on supportive care to prevent stroke complications, physical and occupational therapy, and aggressive addiction rehabilitation.

Original languageEnglish (US)
Pages (from-to)40-45
Number of pages6
JournalCurrent Neurology and Neuroscience Reports
Volume3
Issue number1
DOIs
StatePublished - Jan 1 2003
Externally publishedYes

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Sympathomimetics
Cerebral Infarction
Substance-Related Disorders
Intracranial Hemorrhages
Alcohols
Stroke
Endocarditis
Alcoholism
Intravenous Substance Abuse
Central Nervous System Vasculitis
Occupational Therapy
Street Drugs
Vasoconstriction
Intravenous Administration
Drinking
Rehabilitation
Hemorrhage
Hypertension

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Cerebrovascular complications of alcohol and sympathomimetic drug abuse. / Bruno, Askiel.

In: Current Neurology and Neuroscience Reports, Vol. 3, No. 1, 01.01.2003, p. 40-45.

Research output: Contribution to journalReview article

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