@article{e7deb4be4ff6430cbb6b83fa0fada4ed,
title = "Cerebrovascular complications of diabetes: Focus on cognitive dysfunction",
abstract = "The incidence of diabetes has more than doubled in the United States in the last 30 years and the global disease rate is projected to double by 2030. Cognitive impairment has been associated with diabetes, worsening quality of life in patients. The structural and functional interaction of neurons with the surrounding vasculature is critical for proper function of the central nervous system including domains involved in learning and memory. Thus, in this review we explore cognitive impairment in patients and experimental models, focusing on links to vascular dysfunction and structural changes. Lastly, we propose a role for the innate immunity-mediated inflammation in neurovascular changes in diabetes.",
keywords = "Cerebral vasculature, Cognitive impairment, Diabetes, Vascular",
author = "Trevor Hardigan and Rebecca Ward and Adviye Ergul",
note = "Funding Information: This work was supported by the VA Merit Award [grant number BX000347 (to A.E.)]; VA Research Career Scientists Award (to A.E.); the National Institutes of Health award [grant numbers NS070239 and R01NS083559 (to A.E.)]; and the American Heart Association Predoctoral Fellowship [grant number 15PRE25760034 (to T.H.)]. Funding Information: Adviye Ergul is a Research Career Scientist at the Charlie Norwood Veterans Affairs Medical Center in Augusta, Georgia. The contents do not represent the views of the Department of Veterans Affairs or the United States Government. This work was supported by the VA Merit Award [grant number BX000347 (to A.E.)]; VA Research Career Scientists Award (to A.E.); the National Institutes of Health award [grant numbers NS070239 and R01NS083559 (to A.E.)]; and the American Heart Association Predoctoral Fellowship [grant number 15PRE25760034 (to T.H.)]. Publisher Copyright: {\textcopyright} 2016 The Author(s).",
year = "2016",
doi = "10.1042/CS20160397",
language = "English (US)",
volume = "130",
pages = "1807--1822",
journal = "Clinical Science",
issn = "0143-5221",
publisher = "Portland Press Ltd.",
number = "20",
}