Challenges and opportunities in linking long noncoding RNAs to cardiovascular, lung, and blood diseases

Jane E. Freedman, Joseph M. Miano

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

The new millennium heralds an unanticipated surge of genomic information, most notably an expansive class of long noncoding RNAs (lncRNAs). These transcripts, which now outnumber all protein-coding genes, often exhibit the same characteristics as mRNAs (RNA polymerase II-dependent, 5′ methyl-capped, multiexonic, polyadenylated); yet, they do not encode for stable, well-conserved proteins. Elucidating the function of all relevant lncRNAs in heart, vasculature, lung, and blood is essential for generating a complete interactome in these tissues. This is particularly evident because an increasing number of investigators perform RNA-sequencing experiments where, typically, annotated lncRNAs exhibit impressive changes in gene expression. How does one go about evaluating an lncRNA when the sequence of the transcript lends no insight into how it may function within a cell type? Here, we provide a brief overview for the rational study of lncRNAs.

Original languageEnglish (US)
Pages (from-to)21-25
Number of pages5
JournalArteriosclerosis, thrombosis, and vascular biology
Volume37
Issue number1
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Keywords

  • CRISPR
  • disease
  • genomics
  • method
  • noncoding RNA

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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