Abstract
Use of argatroban as an alternative to heparin during cardiopulmonary bypass (CPB) in patients with heparin-induced thrombocytopenia has gained some attention in the past two decades. Dosing of argatroban during CPB is complex due to lack of complete understanding of its pharmacokinetic profile and the various elements during CPB that may alter its plasma levels. We report a case where the challenges in dosing argatroban led to failure to provide adequate anticoagulation during CPB, as evidenced by clot formation in the oxygenator, and extensive bleeding in the postoperative period.
Original language | English (US) |
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Pages (from-to) | 106-110 |
Number of pages | 5 |
Journal | Journal of Anaesthesiology Clinical Pharmacology |
Volume | 28 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2012 |
Externally published | Yes |
Keywords
- Anti-coagulation
- argatroban
- cardio-pulmonary bypass
- heparin alternative
- heparin induced thrombocytopenia
ASJC Scopus subject areas
- General Pharmacology, Toxicology and Pharmaceutics
- Pharmacology (medical)
- Anesthesiology and Pain Medicine