TY - JOUR
T1 - Challenging a “cushy” life
T2 - Potential roles of thermogenesis and adipose tissue adaptations in delayed aging of ames and snell dwarf mice
AU - Valencak, Teresa G.
AU - Spenlingwimmer, Tanja
AU - Nimphy, Ricarda
AU - Reinisch, Isabel
AU - Hoffman, Jessica M.
AU - Prokesch, Andreas
N1 - Funding Information:
TGV was funded by the Austrian Science Foundation (FWF) when collecting the data presented here (V197-B17 and P22323-B17). AP received funding from the Austrian Science Foundation (FWF, projects I3165 and P29328-B26). JMH is funded by the United States National Institute on Aging within the National Institutes of Health (K99AG059920).
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access.
PY - 2020/5
Y1 - 2020/5
N2 - Laboratory mouse models with genetically altered growth hormone (GH) signaling and subsequent endocrine disruptions, have longer lifespans than control littermates. As such, these mice are commonly examined to determine the role of the somatotropic axis as it relates to healthspan and longevity in mammals. The two most prominent mouse mutants in this context are the genetically dwarf Ames and Snell models which have been studied extensively for over two decades. However, it has only been proposed recently that both white and brown adipose tissue depots may contribute to their delayed aging. Here we review the current state of the field and supplement it with recent data from our labs.
AB - Laboratory mouse models with genetically altered growth hormone (GH) signaling and subsequent endocrine disruptions, have longer lifespans than control littermates. As such, these mice are commonly examined to determine the role of the somatotropic axis as it relates to healthspan and longevity in mammals. The two most prominent mouse mutants in this context are the genetically dwarf Ames and Snell models which have been studied extensively for over two decades. However, it has only been proposed recently that both white and brown adipose tissue depots may contribute to their delayed aging. Here we review the current state of the field and supplement it with recent data from our labs.
KW - Brown adipose tissue
KW - IGF-1
KW - Lipids
KW - Pituitary specific factor 1 (Pit-I)
KW - Prophet of Pituitary 1 (PropI)
KW - White adipose tissue
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U2 - 10.3390/metabo10050176
DO - 10.3390/metabo10050176
M3 - Article
AN - SCOPUS:85084138405
SN - 2218-1989
VL - 10
JO - Metabolites
JF - Metabolites
IS - 5
M1 - 176
ER -