Challenging a “cushy” life: Potential roles of thermogenesis and adipose tissue adaptations in delayed aging of ames and snell dwarf mice

Teresa G. Valencak, Tanja Spenlingwimmer, Ricarda Nimphy, Isabel Reinisch, Jessica M. Hoffman, Andreas Prokesch

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Laboratory mouse models with genetically altered growth hormone (GH) signaling and subsequent endocrine disruptions, have longer lifespans than control littermates. As such, these mice are commonly examined to determine the role of the somatotropic axis as it relates to healthspan and longevity in mammals. The two most prominent mouse mutants in this context are the genetically dwarf Ames and Snell models which have been studied extensively for over two decades. However, it has only been proposed recently that both white and brown adipose tissue depots may contribute to their delayed aging. Here we review the current state of the field and supplement it with recent data from our labs.

Original languageEnglish (US)
Article number176
JournalMetabolites
Volume10
Issue number5
DOIs
StatePublished - May 2020
Externally publishedYes

Keywords

  • Brown adipose tissue
  • IGF-1
  • Lipids
  • Pituitary specific factor 1 (Pit-I)
  • Prophet of Pituitary 1 (PropI)
  • White adipose tissue

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Biology

Fingerprint

Dive into the research topics of 'Challenging a “cushy” life: Potential roles of thermogenesis and adipose tissue adaptations in delayed aging of ames and snell dwarf mice'. Together they form a unique fingerprint.

Cite this