Change in pulmonary function tests in normal males and females after exposure to 15,000 feet of simulated altitude

Nancy P. Lawless, Thomas A Dillard, K. Torrington, Q. Davis, G. Kamimori

Research output: Contribution to journalArticle

Abstract

Purpose: The primary method of adapting to the stress of altitude is increasing ventilation. We measured pulmonary function tests (PFTs) before and after a normobaric hypoxic exposure to further define the alterations in PFTs after altitude exposure. Methods: Sixteen healthy subjects (8 male, 8 female) ages 18-32 were exposed to 12% oxygen, 88% nitrogen gas mixture (equivalent to 15,000 feet) via a clear plastic hood for 8 hours. The average PaO2 at sea level was 110 mmHg; at altitude PaO2 was 45 mmHg. Pulmonary function tests were performed prior to exposure and immediately after exposure. Results: Males FVC(L) FEV1(L) DLCO TLC(L) Pre 5.18 3.98 33.4 7.34 Post 4.92 3.85 32.1 6.22 P value .002 .077 .376 .030 Females FVC(L) FEV1(L) DLCO TLC(L) Pre 3.33 2.75 27.0 4.62 Post 3.27 2.73 26.4 4.72 P value .605 .786 .551 .289 All FVC(L) FEV1(L) DLCO TLC(L) Pre 4.25 3.36 30.2 5.98 Post 4.10 3.29 29.3 5.47 P value .025 .154 .263 .067 Our data show a small but significant decrease in FVC after normobaric hypoxic exposure, without significant change in other pulmonary function tests. Subgroup analysis showed significant decline in FVC and TLC in males that did not occur in females. Conclusions: The majority of prior studies used only male subjects and show small but significant decline in FVC after exposure to altitude. Our combined and male-only data are consistent with prior altitude exposures in both the direction and magnitude of change in PFTs. The lack of effect of altitude in females warrants further investigation. Clinical Implications: Change in lung function caused by altitude could exacerbate altitude-induced hypoxia and may be more significant in males.

Original languageEnglish (US)
JournalCHEST
Volume110
Issue number4 SUPPL.
StatePublished - Oct 1 1996

Fingerprint

Respiratory Function Tests
Altitude Sickness
Oceans and Seas
Plastics
Ventilation
Healthy Volunteers
Nitrogen
Gases
Oxygen
Lung

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Lawless, N. P., Dillard, T. A., Torrington, K., Davis, Q., & Kamimori, G. (1996). Change in pulmonary function tests in normal males and females after exposure to 15,000 feet of simulated altitude. CHEST, 110(4 SUPPL.).

Change in pulmonary function tests in normal males and females after exposure to 15,000 feet of simulated altitude. / Lawless, Nancy P.; Dillard, Thomas A; Torrington, K.; Davis, Q.; Kamimori, G.

In: CHEST, Vol. 110, No. 4 SUPPL., 01.10.1996.

Research output: Contribution to journalArticle

Lawless, NP, Dillard, TA, Torrington, K, Davis, Q & Kamimori, G 1996, 'Change in pulmonary function tests in normal males and females after exposure to 15,000 feet of simulated altitude', CHEST, vol. 110, no. 4 SUPPL..
Lawless NP, Dillard TA, Torrington K, Davis Q, Kamimori G. Change in pulmonary function tests in normal males and females after exposure to 15,000 feet of simulated altitude. CHEST. 1996 Oct 1;110(4 SUPPL.).
Lawless, Nancy P. ; Dillard, Thomas A ; Torrington, K. ; Davis, Q. ; Kamimori, G. / Change in pulmonary function tests in normal males and females after exposure to 15,000 feet of simulated altitude. In: CHEST. 1996 ; Vol. 110, No. 4 SUPPL.
@article{441240b2beaa47e5836a6b4e7ff91bf7,
title = "Change in pulmonary function tests in normal males and females after exposure to 15,000 feet of simulated altitude",
abstract = "Purpose: The primary method of adapting to the stress of altitude is increasing ventilation. We measured pulmonary function tests (PFTs) before and after a normobaric hypoxic exposure to further define the alterations in PFTs after altitude exposure. Methods: Sixteen healthy subjects (8 male, 8 female) ages 18-32 were exposed to 12{\%} oxygen, 88{\%} nitrogen gas mixture (equivalent to 15,000 feet) via a clear plastic hood for 8 hours. The average PaO2 at sea level was 110 mmHg; at altitude PaO2 was 45 mmHg. Pulmonary function tests were performed prior to exposure and immediately after exposure. Results: Males FVC(L) FEV1(L) DLCO TLC(L) Pre 5.18 3.98 33.4 7.34 Post 4.92 3.85 32.1 6.22 P value .002 .077 .376 .030 Females FVC(L) FEV1(L) DLCO TLC(L) Pre 3.33 2.75 27.0 4.62 Post 3.27 2.73 26.4 4.72 P value .605 .786 .551 .289 All FVC(L) FEV1(L) DLCO TLC(L) Pre 4.25 3.36 30.2 5.98 Post 4.10 3.29 29.3 5.47 P value .025 .154 .263 .067 Our data show a small but significant decrease in FVC after normobaric hypoxic exposure, without significant change in other pulmonary function tests. Subgroup analysis showed significant decline in FVC and TLC in males that did not occur in females. Conclusions: The majority of prior studies used only male subjects and show small but significant decline in FVC after exposure to altitude. Our combined and male-only data are consistent with prior altitude exposures in both the direction and magnitude of change in PFTs. The lack of effect of altitude in females warrants further investigation. Clinical Implications: Change in lung function caused by altitude could exacerbate altitude-induced hypoxia and may be more significant in males.",
author = "Lawless, {Nancy P.} and Dillard, {Thomas A} and K. Torrington and Q. Davis and G. Kamimori",
year = "1996",
month = "10",
day = "1",
language = "English (US)",
volume = "110",
journal = "Chest",
issn = "0012-3692",
publisher = "American College of Chest Physicians",
number = "4 SUPPL.",

}

TY - JOUR

T1 - Change in pulmonary function tests in normal males and females after exposure to 15,000 feet of simulated altitude

AU - Lawless, Nancy P.

AU - Dillard, Thomas A

AU - Torrington, K.

AU - Davis, Q.

AU - Kamimori, G.

PY - 1996/10/1

Y1 - 1996/10/1

N2 - Purpose: The primary method of adapting to the stress of altitude is increasing ventilation. We measured pulmonary function tests (PFTs) before and after a normobaric hypoxic exposure to further define the alterations in PFTs after altitude exposure. Methods: Sixteen healthy subjects (8 male, 8 female) ages 18-32 were exposed to 12% oxygen, 88% nitrogen gas mixture (equivalent to 15,000 feet) via a clear plastic hood for 8 hours. The average PaO2 at sea level was 110 mmHg; at altitude PaO2 was 45 mmHg. Pulmonary function tests were performed prior to exposure and immediately after exposure. Results: Males FVC(L) FEV1(L) DLCO TLC(L) Pre 5.18 3.98 33.4 7.34 Post 4.92 3.85 32.1 6.22 P value .002 .077 .376 .030 Females FVC(L) FEV1(L) DLCO TLC(L) Pre 3.33 2.75 27.0 4.62 Post 3.27 2.73 26.4 4.72 P value .605 .786 .551 .289 All FVC(L) FEV1(L) DLCO TLC(L) Pre 4.25 3.36 30.2 5.98 Post 4.10 3.29 29.3 5.47 P value .025 .154 .263 .067 Our data show a small but significant decrease in FVC after normobaric hypoxic exposure, without significant change in other pulmonary function tests. Subgroup analysis showed significant decline in FVC and TLC in males that did not occur in females. Conclusions: The majority of prior studies used only male subjects and show small but significant decline in FVC after exposure to altitude. Our combined and male-only data are consistent with prior altitude exposures in both the direction and magnitude of change in PFTs. The lack of effect of altitude in females warrants further investigation. Clinical Implications: Change in lung function caused by altitude could exacerbate altitude-induced hypoxia and may be more significant in males.

AB - Purpose: The primary method of adapting to the stress of altitude is increasing ventilation. We measured pulmonary function tests (PFTs) before and after a normobaric hypoxic exposure to further define the alterations in PFTs after altitude exposure. Methods: Sixteen healthy subjects (8 male, 8 female) ages 18-32 were exposed to 12% oxygen, 88% nitrogen gas mixture (equivalent to 15,000 feet) via a clear plastic hood for 8 hours. The average PaO2 at sea level was 110 mmHg; at altitude PaO2 was 45 mmHg. Pulmonary function tests were performed prior to exposure and immediately after exposure. Results: Males FVC(L) FEV1(L) DLCO TLC(L) Pre 5.18 3.98 33.4 7.34 Post 4.92 3.85 32.1 6.22 P value .002 .077 .376 .030 Females FVC(L) FEV1(L) DLCO TLC(L) Pre 3.33 2.75 27.0 4.62 Post 3.27 2.73 26.4 4.72 P value .605 .786 .551 .289 All FVC(L) FEV1(L) DLCO TLC(L) Pre 4.25 3.36 30.2 5.98 Post 4.10 3.29 29.3 5.47 P value .025 .154 .263 .067 Our data show a small but significant decrease in FVC after normobaric hypoxic exposure, without significant change in other pulmonary function tests. Subgroup analysis showed significant decline in FVC and TLC in males that did not occur in females. Conclusions: The majority of prior studies used only male subjects and show small but significant decline in FVC after exposure to altitude. Our combined and male-only data are consistent with prior altitude exposures in both the direction and magnitude of change in PFTs. The lack of effect of altitude in females warrants further investigation. Clinical Implications: Change in lung function caused by altitude could exacerbate altitude-induced hypoxia and may be more significant in males.

UR - http://www.scopus.com/inward/record.url?scp=33750281524&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750281524&partnerID=8YFLogxK

M3 - Article

VL - 110

JO - Chest

JF - Chest

SN - 0012-3692

IS - 4 SUPPL.

ER -