Changes in autonomic responsiveness following bilateral amygdalotomyin humans

Gregory P Lee, John G. Arena, Kimford J. Meador, Joseph R. Smith, David W. Loring, Herman F. Flanigin

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Although reports of human amygdalotomy for intractable behavioral disturbances generally indicate positive outcomes regarding diminished episodes of rage, the mechanisms by which these changes occur are not well understood. The amygdala has been described as a sensory modulator of emotional responses, and its importance in mediating certain autonomic nervous system functions may account, in part, for this functional description. In order to examine the amygdala's role in autonomic activity, we measured autonomic responsiveness and habituation in a patient who underwent bilateral amygdalotomy for intractable aggression. Preoperatively, there was no evidence of electrodermal response habituation, whereas postoperatively, habituation occurred normally. Electrodermal response, frontal electromyography, and hand temperature showed a consistent change, indicating diminished autonomic levels following surgery. These findings suggest that the beneficial results reported for bilateral amygdalotomy in reducing episodes of aggression may be associated with diminished autonomic responsiveness.

Original languageEnglish (US)
Pages (from-to)119-129
Number of pages11
JournalNeuropsychiatry, Neuropsychology and Behavioral Neurology
Volume1
Issue number2
StatePublished - Jan 1 1988

Fingerprint

Galvanic Skin Response
Amygdala
Aggression
Rage
Autonomic Nervous System
Electromyography
Hand
Temperature

Keywords

  • Amygdala
  • Autonomic nervous system
  • Psychosurgery

ASJC Scopus subject areas

  • Psychology(all)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Lee, G. P., Arena, J. G., Meador, K. J., Smith, J. R., Loring, D. W., & Flanigin, H. F. (1988). Changes in autonomic responsiveness following bilateral amygdalotomyin humans. Neuropsychiatry, Neuropsychology and Behavioral Neurology, 1(2), 119-129.

Changes in autonomic responsiveness following bilateral amygdalotomyin humans. / Lee, Gregory P; Arena, John G.; Meador, Kimford J.; Smith, Joseph R.; Loring, David W.; Flanigin, Herman F.

In: Neuropsychiatry, Neuropsychology and Behavioral Neurology, Vol. 1, No. 2, 01.01.1988, p. 119-129.

Research output: Contribution to journalArticle

Lee, GP, Arena, JG, Meador, KJ, Smith, JR, Loring, DW & Flanigin, HF 1988, 'Changes in autonomic responsiveness following bilateral amygdalotomyin humans', Neuropsychiatry, Neuropsychology and Behavioral Neurology, vol. 1, no. 2, pp. 119-129.
Lee GP, Arena JG, Meador KJ, Smith JR, Loring DW, Flanigin HF. Changes in autonomic responsiveness following bilateral amygdalotomyin humans. Neuropsychiatry, Neuropsychology and Behavioral Neurology. 1988 Jan 1;1(2):119-129.
Lee, Gregory P ; Arena, John G. ; Meador, Kimford J. ; Smith, Joseph R. ; Loring, David W. ; Flanigin, Herman F. / Changes in autonomic responsiveness following bilateral amygdalotomyin humans. In: Neuropsychiatry, Neuropsychology and Behavioral Neurology. 1988 ; Vol. 1, No. 2. pp. 119-129.
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