Changes in cardiac glycoside activity produced by aminosugar addition

L. S. Cook, Robert William Caldwell, C. B. Nash

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In anesthetized dogs, structure activity relationships among three cardiotonic compounds were determined by comparing the cardiovascular effects of digotoxigenin (the genin) to digitoxigenin-galactose (a genin-neutral sugar combination) and to digitoxigenin-aminogalactose (ASI-222, a genin-aminosugar combination) using either bolus i.v. injections or constant i.v. infusion. We recorded the effects of these drugs upon cardiac rate, mean blood pressure, left ventricular dP/dt, cardiac index, systolic time intervals, tension-time index, therapeutic index, ventricular excitability and the ventricular refractory period. The addition of an aminosugar group to digitoxigenin or an amine group to galactose-digitoxigenin results in an agent with greater ability to reduce heart rate and to increase cardiac contractility and cardiac index without affecting the tension-time index. Moreover, the addition of an amino group significantly increased the therapeutic index and ventricular refractory period but reduced the toxic index (lethal dose/toxic) when compared to the neutral-sugar cardenolide and genin. Our data indicate that such a substitution confers greater potency, prolongs the duration of activity and results in a compound with greater therapeutic index.

Original languageEnglish (US)
Pages (from-to)198-204
Number of pages7
JournalJournal of Pharmacology and Experimental Therapeutics
Volume215
Issue number1
StatePublished - Dec 1 1980

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Cardiac Glycosides
Digitoxigenin
Poisons
Cardenolides
Cardiotonic Agents
Systole
Structure-Activity Relationship
Amines
Therapeutics
Heart Rate
Dogs
Blood Pressure
Injections
Pharmaceutical Preparations
digitoxigenin-galactose

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Changes in cardiac glycoside activity produced by aminosugar addition. / Cook, L. S.; Caldwell, Robert William; Nash, C. B.

In: Journal of Pharmacology and Experimental Therapeutics, Vol. 215, No. 1, 01.12.1980, p. 198-204.

Research output: Contribution to journalArticle

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