Changes in cerebrospinal fluid Na+ concentration do not underlie hypertensive responses to dietary NaCl in spontaneously hypertensive rats

Mahmood S Mozaffari, S. Jirakulsomchok, S. Oparil, J. M. Wyss

Research output: Contribution to journalArticle

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Abstract

This study tests the hypothesis that dietary NaCl loading increases cerebrospinal fluid (CSF) Na+ concentration in NaCl-sensitive spontaneously hypertensive rats (SHR-S), resulting in an increase in arterial pressure. The high NaCl diet caused a significant rise in systolic arterial pressure in SHR-S but not in normotensive Wistar Kyoto (WKY) rats. In contrast, the high NaCl diet caused a transient rise in CSF Na+ that was similar in amplitude in SHR-S and WKY. A second experiment demonstrated that in SHR-S, concomitant dietary Ca2+ supplementation attenuated the dietary NaCl-induced exacerbation of hypertension, but did not alter the transient increase in CSF Na+ concentration. Together, these results indicate that alterations in CSF Na+ concentration do not contribute to the increase in arterial pressure induced by a high NaCl diet in SHR-S.

Original languageEnglish (US)
Pages (from-to)149-152
Number of pages4
JournalBrain Research
Volume506
Issue number1
DOIs
Publication statusPublished - Jan 1 1990

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Keywords

  • Adrenoceptor
  • Hypertension
  • Hypothalamus
  • Noradrenaline
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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