Changes in cerebrospinal fluid Na+ concentration do not underlie hypertensive responses to dietary NaCl in spontaneously hypertensive rats

Mahmood S Mozaffari, S. Jirakulsomchok, S. Oparil, J. M. Wyss

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

This study tests the hypothesis that dietary NaCl loading increases cerebrospinal fluid (CSF) Na+ concentration in NaCl-sensitive spontaneously hypertensive rats (SHR-S), resulting in an increase in arterial pressure. The high NaCl diet caused a significant rise in systolic arterial pressure in SHR-S but not in normotensive Wistar Kyoto (WKY) rats. In contrast, the high NaCl diet caused a transient rise in CSF Na+ that was similar in amplitude in SHR-S and WKY. A second experiment demonstrated that in SHR-S, concomitant dietary Ca2+ supplementation attenuated the dietary NaCl-induced exacerbation of hypertension, but did not alter the transient increase in CSF Na+ concentration. Together, these results indicate that alterations in CSF Na+ concentration do not contribute to the increase in arterial pressure induced by a high NaCl diet in SHR-S.

Original languageEnglish (US)
Pages (from-to)149-152
Number of pages4
JournalBrain Research
Volume506
Issue number1
DOIs
StatePublished - Jan 1 1990

Fingerprint

Inbred SHR Rats
Cerebrospinal Fluid
Arterial Pressure
Diet
Inbred WKY Rats
Dietary Supplements
Blood Pressure
Hypertension

Keywords

  • Adrenoceptor
  • Hypertension
  • Hypothalamus
  • Noradrenaline
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Changes in cerebrospinal fluid Na+ concentration do not underlie hypertensive responses to dietary NaCl in spontaneously hypertensive rats. / Mozaffari, Mahmood S; Jirakulsomchok, S.; Oparil, S.; Wyss, J. M.

In: Brain Research, Vol. 506, No. 1, 01.01.1990, p. 149-152.

Research output: Contribution to journalArticle

@article{39a1dbfd6b184e58b5595b3d79308a35,
title = "Changes in cerebrospinal fluid Na+ concentration do not underlie hypertensive responses to dietary NaCl in spontaneously hypertensive rats",
abstract = "This study tests the hypothesis that dietary NaCl loading increases cerebrospinal fluid (CSF) Na+ concentration in NaCl-sensitive spontaneously hypertensive rats (SHR-S), resulting in an increase in arterial pressure. The high NaCl diet caused a significant rise in systolic arterial pressure in SHR-S but not in normotensive Wistar Kyoto (WKY) rats. In contrast, the high NaCl diet caused a transient rise in CSF Na+ that was similar in amplitude in SHR-S and WKY. A second experiment demonstrated that in SHR-S, concomitant dietary Ca2+ supplementation attenuated the dietary NaCl-induced exacerbation of hypertension, but did not alter the transient increase in CSF Na+ concentration. Together, these results indicate that alterations in CSF Na+ concentration do not contribute to the increase in arterial pressure induced by a high NaCl diet in SHR-S.",
keywords = "Adrenoceptor, Hypertension, Hypothalamus, Noradrenaline, Sympathetic nervous system",
author = "Mozaffari, {Mahmood S} and S. Jirakulsomchok and S. Oparil and Wyss, {J. M.}",
year = "1990",
month = "1",
day = "1",
doi = "10.1016/0006-8993(90)91212-Y",
language = "English (US)",
volume = "506",
pages = "149--152",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Changes in cerebrospinal fluid Na+ concentration do not underlie hypertensive responses to dietary NaCl in spontaneously hypertensive rats

AU - Mozaffari, Mahmood S

AU - Jirakulsomchok, S.

AU - Oparil, S.

AU - Wyss, J. M.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - This study tests the hypothesis that dietary NaCl loading increases cerebrospinal fluid (CSF) Na+ concentration in NaCl-sensitive spontaneously hypertensive rats (SHR-S), resulting in an increase in arterial pressure. The high NaCl diet caused a significant rise in systolic arterial pressure in SHR-S but not in normotensive Wistar Kyoto (WKY) rats. In contrast, the high NaCl diet caused a transient rise in CSF Na+ that was similar in amplitude in SHR-S and WKY. A second experiment demonstrated that in SHR-S, concomitant dietary Ca2+ supplementation attenuated the dietary NaCl-induced exacerbation of hypertension, but did not alter the transient increase in CSF Na+ concentration. Together, these results indicate that alterations in CSF Na+ concentration do not contribute to the increase in arterial pressure induced by a high NaCl diet in SHR-S.

AB - This study tests the hypothesis that dietary NaCl loading increases cerebrospinal fluid (CSF) Na+ concentration in NaCl-sensitive spontaneously hypertensive rats (SHR-S), resulting in an increase in arterial pressure. The high NaCl diet caused a significant rise in systolic arterial pressure in SHR-S but not in normotensive Wistar Kyoto (WKY) rats. In contrast, the high NaCl diet caused a transient rise in CSF Na+ that was similar in amplitude in SHR-S and WKY. A second experiment demonstrated that in SHR-S, concomitant dietary Ca2+ supplementation attenuated the dietary NaCl-induced exacerbation of hypertension, but did not alter the transient increase in CSF Na+ concentration. Together, these results indicate that alterations in CSF Na+ concentration do not contribute to the increase in arterial pressure induced by a high NaCl diet in SHR-S.

KW - Adrenoceptor

KW - Hypertension

KW - Hypothalamus

KW - Noradrenaline

KW - Sympathetic nervous system

UR - http://www.scopus.com/inward/record.url?scp=0025139689&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025139689&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(90)91212-Y

DO - 10.1016/0006-8993(90)91212-Y

M3 - Article

VL - 506

SP - 149

EP - 152

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -