Changes in peak airflow measurement during maximal cough after vocal fold augmentation in patients with glottic insufficiency

Gregory R. Dion, Efstratios Achlatis, Stephanie Erh Shuen Teng, Yixin Fang, Michael Persky, Ryan C. Branski, Milan R. Amin

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

IMPORTANCE: Compromised cough effectiveness is correlated with dysphagia and aspiration. Glottic insufficiency likely yields decreased cough strength and effectiveness. Although vocal fold augmentation favorably affects voice and likely improves cough strength, few data exist to support this hypothesis. OBJECTIVE: To assess whether vocal fold augmentation improves peak airflow measurements during maximal-effort cough following augmentation. DESIGN, SETTING, AND PARTICIPANTS: This case series study was conducted in a tertiary, academic laryngology clinic. Participants included 14 consecutive individuals with glottic insufficiency due to vocal fold paralysis, which was diagnosed via videostrobolaryngoscopy as a component of routine clinical examination. All participants who chose to proceed with augmentation were considered for the study whether office-based or operative augmentation was planned. Postaugmentation data were collected only at the first follow-up visit, which was targeted for 14 days after augmentation but varied on the basis of participant availability. Data were collected from June 5, 2014, to October 1, 2015. Data analysis took place between October 2, 2015, and March 3, 2017. MAIN OUTCOMES AND MEASURES: Peak airflow during maximal volitional cough was quantified before and after vocal fold augmentation. Participants performed maximal coughs, and peak expiratory flow during the maximal cough was captured according to American Thoracic Society guidelines. RESULTS Among the 14 participants (7 men and 7 women), the mean (SD) age was 62 (18) years. Three types of injectable material were used for vocal fold augmentation: carboxymethylcellulose in 5 patients, hyaluronic acid in 5, and calcium hydroxylapatite in 4. Following augmentation, cough strength increased in 11 participants and decreased cough strength was observed in 3. Peak airflow measurements during maximal cough varied from a decrease of 40 L/min to an increase of 150 L/min following augmentation. When preaugmentation and postaugmentation peak airflow measurements were compared, the median improvement was 50 L/min (95% CI, 10-75 L/min; P = .01). Immediate peak airflow measurements during cough collected within 30 minutes of augmentation varied when compared with measurements collected at follow-up (103-380 vs 160-390 L/min). CONCLUSIONS AND RELEVANCE: Peak airflow during maximal cough may improve with vocal fold augmentation. Additional assessment and measurements are needed to further delineate which patients will benefit most regarding their cough from vocal fold augmentation.

Original languageEnglish (US)
Pages (from-to)1141-1145
Number of pages5
JournalJAMA Otolaryngology - Head and Neck Surgery
Volume143
Issue number11
DOIs
StatePublished - Nov 1 2017
Externally publishedYes

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Vocal Cords
Tongue
Cough
Carboxymethylcellulose Sodium
Otolaryngology
Hyaluronic Acid
Durapatite
Deglutition Disorders
Paralysis

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

Cite this

Changes in peak airflow measurement during maximal cough after vocal fold augmentation in patients with glottic insufficiency. / Dion, Gregory R.; Achlatis, Efstratios; Teng, Stephanie Erh Shuen; Fang, Yixin; Persky, Michael; Branski, Ryan C.; Amin, Milan R.

In: JAMA Otolaryngology - Head and Neck Surgery, Vol. 143, No. 11, 01.11.2017, p. 1141-1145.

Research output: Contribution to journalArticle

Dion, Gregory R. ; Achlatis, Efstratios ; Teng, Stephanie Erh Shuen ; Fang, Yixin ; Persky, Michael ; Branski, Ryan C. ; Amin, Milan R. / Changes in peak airflow measurement during maximal cough after vocal fold augmentation in patients with glottic insufficiency. In: JAMA Otolaryngology - Head and Neck Surgery. 2017 ; Vol. 143, No. 11. pp. 1141-1145.
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N2 - IMPORTANCE: Compromised cough effectiveness is correlated with dysphagia and aspiration. Glottic insufficiency likely yields decreased cough strength and effectiveness. Although vocal fold augmentation favorably affects voice and likely improves cough strength, few data exist to support this hypothesis. OBJECTIVE: To assess whether vocal fold augmentation improves peak airflow measurements during maximal-effort cough following augmentation. DESIGN, SETTING, AND PARTICIPANTS: This case series study was conducted in a tertiary, academic laryngology clinic. Participants included 14 consecutive individuals with glottic insufficiency due to vocal fold paralysis, which was diagnosed via videostrobolaryngoscopy as a component of routine clinical examination. All participants who chose to proceed with augmentation were considered for the study whether office-based or operative augmentation was planned. Postaugmentation data were collected only at the first follow-up visit, which was targeted for 14 days after augmentation but varied on the basis of participant availability. Data were collected from June 5, 2014, to October 1, 2015. Data analysis took place between October 2, 2015, and March 3, 2017. MAIN OUTCOMES AND MEASURES: Peak airflow during maximal volitional cough was quantified before and after vocal fold augmentation. Participants performed maximal coughs, and peak expiratory flow during the maximal cough was captured according to American Thoracic Society guidelines. RESULTS Among the 14 participants (7 men and 7 women), the mean (SD) age was 62 (18) years. Three types of injectable material were used for vocal fold augmentation: carboxymethylcellulose in 5 patients, hyaluronic acid in 5, and calcium hydroxylapatite in 4. Following augmentation, cough strength increased in 11 participants and decreased cough strength was observed in 3. Peak airflow measurements during maximal cough varied from a decrease of 40 L/min to an increase of 150 L/min following augmentation. When preaugmentation and postaugmentation peak airflow measurements were compared, the median improvement was 50 L/min (95% CI, 10-75 L/min; P = .01). Immediate peak airflow measurements during cough collected within 30 minutes of augmentation varied when compared with measurements collected at follow-up (103-380 vs 160-390 L/min). CONCLUSIONS AND RELEVANCE: Peak airflow during maximal cough may improve with vocal fold augmentation. Additional assessment and measurements are needed to further delineate which patients will benefit most regarding their cough from vocal fold augmentation.

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