Abstract
In concert with studies of the effects of various pharmacologic inhibitors of corticosteroidogenesis on adrenocortical morphology, U-8113, an analog of amphenone B, was administered daily to Sprague-Dawley rats for 7, 14, 21 or 30 days. The primary morphological responses involved increases in adrenal weight, width of zona fasciculata, width of zona reticularis, intracellular lipids, mitochondrial size, mitochondrial vacuolation and crystalline-like inclusions, small coated vesicles, lysosomes, autophagic vacuoles and cholesterol ester clefts. In particular, the increases in lysosomes, coated vesicles and autophagic vacuoles containing morphologically altered mitochondria were considered reflective of mechanisms designed to maintain cellular integrity amidst functional impairment. Lipid analysis revealed marked increases in cholesterol esters and phospholipids, supportive of morphological observations. When permitted a 14 day recovery period following either 14 or 30 days of inhibitor therapy, most fine structural alterations and lipid derangements were diminished, and the cells approximated normal parameters.
Original language | English (US) |
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Pages (from-to) | 123-134 |
Number of pages | 12 |
Journal | Cell and Tissue Research |
Volume | 190 |
Issue number | 1 |
DOIs | |
State | Published - Jun 1978 |
Externally published | Yes |
Keywords
- Adrenal
- Inihibitor
- Steroidogenesis
- Ultrastructure
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology
- Cell Biology