Changes observed in antioxidant system in the blood of post-menopausal women with breast cancer

K. Kumar, Muthusamy Thangaraju, P. Sachdanandam

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

From experimental studies and epidemiological data, it can be inferred that lipid peroxidation is increased in cancer patients. Cases of post-menopausal, untreated women with benign and malignant breast tumours, were compared with their age matched controls in their serum lipid peroxides, antioxidant vitamins (E and C), serum selenium and serum ceruloplasmin. Erythrocyte and its membrane lipid peroxidation and antioxidant enzymes (catalase, superoxide dismutase, glutathione peroxidase and glutathione-S-transferase) levels were also analysed. Significant increase in circulating lipid peroxides, ceruloplasmin and significant decrease in antioxidant vitamins and selenium were observed in breast cancer women. The erythrocyte and its membrane lipid peroxidation was increased significantly and severe impairment of antioxidant potential was observed in breast cancer women.

Original languageEnglish (US)
Pages (from-to)371-380
Number of pages10
JournalBiochemistry International
Volume25
Issue number2
StatePublished - Dec 1 1991
Externally publishedYes

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Blood
Antioxidants
Breast Neoplasms
Lipid Peroxidation
Ceruloplasmin
Lipid Peroxides
Erythrocyte Membrane
Membrane Lipids
Selenium
Serum
Glutathione Peroxidase
Glutathione Transferase
Vitamin E
Vitamins
Catalase
Ascorbic Acid
Superoxide Dismutase
Tumors
Epidemiologic Studies
Lipids

ASJC Scopus subject areas

  • Biochemistry

Cite this

Changes observed in antioxidant system in the blood of post-menopausal women with breast cancer. / Kumar, K.; Thangaraju, Muthusamy; Sachdanandam, P.

In: Biochemistry International, Vol. 25, No. 2, 01.12.1991, p. 371-380.

Research output: Contribution to journalArticle

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