Changes observed in antioxidant system in the blood of post-menopausal women with breast cancer

K. Kumar, M. Thangaraju, P. Sachdanandam

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Abstract

From experimental studies and epidemiological data, it can be inferred that lipid peroxidation is increased in cancer patients. Cases of post-menopausal, untreated women with benign and malignant breast tumours, were compared with their age matched controls in their serum lipid peroxides, antioxidant vitamins (E and C), serum selenium and serum ceruloplasmin. Erythrocyte and its membrane lipid peroxidation and antioxidant enzymes (catalase, superoxide dismutase, glutathione peroxidase and glutathione-S-transferase) levels were also analysed. Significant increase in circulating lipid peroxides, ceruloplasmin and significant decrease in antioxidant vitamins and selenium were observed in breast cancer women. The erythrocyte and its membrane lipid peroxidation was increased significantly and severe impairment of antioxidant potential was observed in breast cancer women.

Original languageEnglish (US)
Pages (from-to)371-380
Number of pages10
JournalBiochemistry International
Volume25
Issue number2
Publication statusPublished - Dec 1 1991
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry

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