Changing directions in the study of chemotaxis

Robert R. Kay, Paul Langridge, David Traynor, Oliver Hoeller

Research output: Contribution to journalReview articlepeer-review

140 Scopus citations

Abstract

Chemotaxis - the guided movement of cells in chemical gradients - probably first emerged in our single-celled ancestors and even today is recognizably similar in neutrophils and amoebae. Chemotaxis enables immune cells to reach sites of infection, allows wounds to heal and is crucial for forming embryonic patterns. Furthermore, the manipulation of chemotaxis may help to alleviate disease states, including the metastasis of cancer cells. This review discusses recent results concerning how cells orientate in chemotactic gradients and the role of phosphatidylinositol-3,4,5-trisphosphate, what produces the force for projecting pseudopodia and a new role for the endocytic cycle in movement.

Original languageEnglish (US)
Pages (from-to)455-463
Number of pages9
JournalNature Reviews Molecular Cell Biology
Volume9
Issue number6
DOIs
StatePublished - Jun 10 2008
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Changing directions in the study of chemotaxis'. Together they form a unique fingerprint.

Cite this