Characterization of a phospholipid antigen reacting with serum antibody in patients with peripheral neuropathies and paraproteinemia

Minoru Suzuki, Keiji Suetake, Takeshi Kasama, Toshio Ariga, Meiko Shiina, Susumu Kusunoki, Robert K Yu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A phospholipid antigen that reacted with the serum antibody from a patient with peripheral neuropathy and paraproteinemia with both impaired sensory and motor functions, but not with sera from patients with only impaired sensory functions and healthy controls, was purified from bovine cauda equina as a minor component with a concentration of about 0.6 μg per gram wet-weight tissue. The structure of the phospholipid was characterized as lysophosphatidylinositol by means of thin-layer chromatography, gas-liquid chromatography, and negative-ion fast-atom-bombardment mass spectrometry. The major fatty acid component of this phospholipid was stearic acid (> 81%). Our data suggest the possible involvement of a lysophospholipid antigen in the immunopathogenesis of peripheral neuropathies with severe motor and sensory dysfunctions. There is an intriguing possibility that the difference in immunoreactivity of serum antibodies may underlie the differential clinical manifestations in patients with peripheral neuropathy and paraproteinemia.

Original languageEnglish (US)
Pages (from-to)970-975
Number of pages6
JournalJournal of Neurochemistry
Volume79
Issue number5
DOIs
StatePublished - Dec 17 2001

Fingerprint

Paraproteinemias
Peripheral Nervous System Diseases
Phospholipids
Antigens
Antibodies
Serum
Lysophospholipids
Fast Atom Bombardment Mass Spectrometry
Cauda Equina
Thin layer chromatography
Liquid chromatography
Thin Layer Chromatography
Gas chromatography
Gas Chromatography
Mass spectrometry
Negative ions
Fatty Acids
Ions
Tissue
Weights and Measures

Keywords

  • Cauda equina
  • Lysophosphatidylinositol
  • Paraproteinemia
  • Peripheral neuropathies

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Characterization of a phospholipid antigen reacting with serum antibody in patients with peripheral neuropathies and paraproteinemia. / Suzuki, Minoru; Suetake, Keiji; Kasama, Takeshi; Ariga, Toshio; Shiina, Meiko; Kusunoki, Susumu; Yu, Robert K.

In: Journal of Neurochemistry, Vol. 79, No. 5, 17.12.2001, p. 970-975.

Research output: Contribution to journalArticle

Suzuki, Minoru ; Suetake, Keiji ; Kasama, Takeshi ; Ariga, Toshio ; Shiina, Meiko ; Kusunoki, Susumu ; Yu, Robert K. / Characterization of a phospholipid antigen reacting with serum antibody in patients with peripheral neuropathies and paraproteinemia. In: Journal of Neurochemistry. 2001 ; Vol. 79, No. 5. pp. 970-975.
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