Characterization of GM1 ganglioside by direct inlet chemical ionization mass spectrometry

T. Ariga, R. K. Yu, M. Suzuki

Research output: Contribution to journalArticle

25 Scopus citations


Intact permethylated and permethylated-reduced (LiAlH4) derivatives of GM1 ganglioside were analyzed by direct inlet ammonia chemical ionization (CI) mass spectrometry. In addition, the trimethylsilylated derivative of the permethylated-reduced sample of this ganglioside was similarly analyzed. CI mass spectrometry proves to be a highly satisfactory method for structural studies of GM1 ganglioside because of the simple fragmentation pattern and the presence of prominent molecular ions and fragment ions in the high mass region. Complete information on the carbohydrate sequence and lipophilic composition can be easily obtained.

Original languageEnglish (US)
Pages (from-to)437-442
Number of pages6
JournalJournal of Lipid Research
Issue number3
Publication statusPublished - Jan 1 1982
Externally publishedYes


ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Cell Biology

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