Characterization of muscarinic acetylcholine receptors in human labial salivary glands

Lin Mei, William R. Roeske, Kenneth T. Izutsu, Henry I. Yamamura

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Muscarinic acetylcholine receptors were studied in human labial salivary glands with (-)-[3H]MQNB. The radioligand bound with a Kd value of 150 pM. The density of muscarinic receptors was 220 fmol/mg protein. Most muscarinic antagonists bound to a homogenous population of muscarinic receptors in this tissue. However, the inhibition curves of pirenzepine had a Hill slope of 0.57 and could be analyzed by a two site model. These results suggest that the muscarinic receptors in human labial salivary glands are a mixture of M1 and M3 types.

Original languageEnglish (US)
Pages (from-to)367-370
Number of pages4
JournalEuropean Journal of Pharmacology
Volume176
Issue number3
DOIs
StatePublished - Feb 13 1990

Keywords

  • Labial salivary gland (human)
  • Muscarinic receptor antagonists
  • Muscarinic receptor subtypes

ASJC Scopus subject areas

  • Pharmacology

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