Characterization of muscarinic acetylcholine receptors in human labial salivary glands

Lin Mei, William R. Roeske, Kenneth T. Izutsu, Henry I. Yamamura

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Muscarinic acetylcholine receptors were studied in human labial salivary glands with (-)-[3H]MQNB. The radioligand bound with a Kd value of 150 pM. The density of muscarinic receptors was 220 fmol/mg protein. Most muscarinic antagonists bound to a homogenous population of muscarinic receptors in this tissue. However, the inhibition curves of pirenzepine had a Hill slope of 0.57 and could be analyzed by a two site model. These results suggest that the muscarinic receptors in human labial salivary glands are a mixture of M1 and M3 types.

Original languageEnglish (US)
Pages (from-to)367-370
Number of pages4
JournalEuropean Journal of Pharmacology
Volume176
Issue number3
DOIs
StatePublished - Feb 13 1990

Fingerprint

Muscarinic Receptors
Lip
Salivary Glands
Pirenzepine
Muscarinic Antagonists
Population
Proteins

Keywords

  • Labial salivary gland (human)
  • Muscarinic receptor antagonists
  • Muscarinic receptor subtypes

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Characterization of muscarinic acetylcholine receptors in human labial salivary glands. / Mei, Lin; Roeske, William R.; Izutsu, Kenneth T.; Yamamura, Henry I.

In: European Journal of Pharmacology, Vol. 176, No. 3, 13.02.1990, p. 367-370.

Research output: Contribution to journalArticle

Mei, Lin ; Roeske, William R. ; Izutsu, Kenneth T. ; Yamamura, Henry I. / Characterization of muscarinic acetylcholine receptors in human labial salivary glands. In: European Journal of Pharmacology. 1990 ; Vol. 176, No. 3. pp. 367-370.
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