Characterization of rare mammary tumours appearing on the neck of riii/sa mice infected with mouse mammary tumour virus

N. H. Sarkar, J. L. Borke, Roni Jacob Bollag

Research output: Contribution to journalArticle

Abstract

RIII/Sa and C3H mice harbour milk-borne mouse mammary tumour virus (MMTV) and develop mammary tumours at a high incidence. These mammary tumours usually arise ventrally and/or on the sides of the animals. In the present study, some mice of both strains were observed to have tumours in the dorsal neck area. Histological analysis of the tumours indicated their similarity to mammary tumours induced by MMTV oncogenesis. The neck tumours were found by thin-section electron microscopy to contain both type A and type B particles that are hallmarks of MMTV infection. In addition, the neck tumour DNA possessed insertion mutations of Wnt-1 and Fgf-3 proto-oncogenes, the activation of which play important roles in the development of mouse mammary tumours. These neck tumours appear to be mammary tumours that arise in the context of in-situ mammary tissue, similar to rare 'ectopic' human breast cancers that arise in the axillary region and other sites remote from the breast.

Original languageEnglish (US)
Pages (from-to)40-47
Number of pages8
JournalJournal of Comparative Pathology
Volume149
Issue number1
DOIs
StatePublished - Jul 1 2013

Fingerprint

Mouse mammary tumor virus
mammary neoplasms (animal)
neck
Neck
Breast Neoplasms
neoplasms
mice
breasts
Neoplasms
Tumor Virus Infections
Breast
proto-oncogenes
Proto-Oncogenes
Inbred C3H Mouse
Insertional Mutagenesis
breast neoplasms
carcinogenesis
electron microscopy
Electron Microscopy
Carcinogenesis

Keywords

  • Ectopic breast cancer
  • Mouse mammary tumour virus
  • Neck tumour
  • Oncogene

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • veterinary(all)

Cite this

Characterization of rare mammary tumours appearing on the neck of riii/sa mice infected with mouse mammary tumour virus. / Sarkar, N. H.; Borke, J. L.; Bollag, Roni Jacob.

In: Journal of Comparative Pathology, Vol. 149, No. 1, 01.07.2013, p. 40-47.

Research output: Contribution to journalArticle

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