Characterization of the breakpoints in a t(8;13)(p11;q12) translocation from a patient with myeloproliferative disease using fluorescence in situ hybridization

Olga Chernova, Ivan Still, Matt Kalaycio, Gerald Hoeltge, John Kenneth Cowell

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We used fluorescence in situ hybridization to characterize the molecular position of the breakpoints in a t(8;13)(p11;q12) reciprocal translocation from a patient with an atypical myeloproliferative disorder. This structural chromosome abnormality is characteristic of this specific disease and occurs often as the only chromosome abnormality in the malignant cells. Yeast artificial chromosome (YAC) analysis has demonstrated that the 8p11 breakpoint lies within a region defined by YAC 959A4 and that the 13q12 breakpoint is spanned by YAC 769F9. Identifying the position of the breakpoints in this rearrangement provides the means to search for candidate genes rearranged by this highly specific structural chromosome abnormality.

Original languageEnglish (US)
Pages (from-to)160-165
Number of pages6
JournalGenes Chromosomes and Cancer
Volume21
Issue number2
DOIs
StatePublished - Feb 1 1998
Externally publishedYes

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ASJC Scopus subject areas

  • Cancer Research
  • Genetics

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