Checkpoint kinase 1 in DNA damage response and cell cycle regulation

Mallikarjun Patil, Navjotsingh Pabla, Zheng Dong

Research output: Contribution to journalReview article

100 Scopus citations

Abstract

Originally identified as a mediator of DNA damage response (DDR), checkpoint kinase 1 (Chk1) has a broader role in checkpoint activation in DDR and normal cell cycle regulation. Chk1 activation involves phosphorylation at conserved sites. However, recent work has identified a splice variant of Chk1, which may regulate Chk1 in both DDR and normal cell cycle via molecular interaction. Upon activation, Chk1 phosphorylates a variety of substrate proteins, resulting in the activation of DNA damage checkpoints, cell cycle arrest, DNA repair, and/or cell death. Chk1 and its related signaling may be an effective therapeutic target in diseases such as cancer.

Original languageEnglish (US)
Pages (from-to)4009-4021
Number of pages13
JournalCellular and Molecular Life Sciences
Volume70
Issue number21
DOIs
StatePublished - Nov 1 2013

Keywords

  • Cell cycle
  • Checkpoint
  • Chk1
  • DNA damage

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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