Chemokine function in periodontal disease and oral cavity cancer

Sinem Esra Sahingur, William Andrew Yeudall

Research output: Contribution to journalReview article

50 Citations (Scopus)

Abstract

The chemotactic cytokines, or chemokines, comprise a superfamily of polypeptides with a wide range of activities that include recruitment of immune cells to sites of infection and inflammation, as well as stimulation of cell proliferation. As such, they function as antimicrobial molecules and play a central role in host defenses against pathogen challenge. However, their ability to recruit leukocytes and potentiate or prolong the inflammatory response may have profound implications for the progression of oral diseases such as chronic periodontitis, where tissue destruction may be widespread. Moreover, it is increasingly recognized that chronic inflammation is a key component of tumor progression. Interaction between cancer cells and their microenvironment is mediated in large part by secreted factors such as chemokines, and serves to enhance the malignant phenotype in oral and other cancers. In this article, we will outline the biological and biochemical mechanisms of chemokine action in host-microbiome interactions in periodontal disease and in oral cancer, and how these may overlap and contribute to pathogenesis.

Original languageEnglish (US)
Article number214
JournalFrontiers in immunology
Volume6
Issue numberMAY
DOIs
StatePublished - Jan 1 2015

Fingerprint

Mouth Neoplasms
Periodontal Diseases
Chemokines
Mouth
Mouth Diseases
Personnel Selection
Inflammation
Cellular Microenvironment
Chronic Periodontitis
Microbiota
Neoplasms
Leukocytes
Cell Proliferation
Phenotype
Peptides
Infection

Keywords

  • Chemokine
  • Host-pathogen interactions
  • Inflammation
  • Oral cancer
  • Periodontitis
  • Toll-like receptor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Chemokine function in periodontal disease and oral cavity cancer. / Sahingur, Sinem Esra; Yeudall, William Andrew.

In: Frontiers in immunology, Vol. 6, No. MAY, 214, 01.01.2015.

Research output: Contribution to journalReview article

@article{96b37e6684534a8d9ff27e763a061f5b,
title = "Chemokine function in periodontal disease and oral cavity cancer",
abstract = "The chemotactic cytokines, or chemokines, comprise a superfamily of polypeptides with a wide range of activities that include recruitment of immune cells to sites of infection and inflammation, as well as stimulation of cell proliferation. As such, they function as antimicrobial molecules and play a central role in host defenses against pathogen challenge. However, their ability to recruit leukocytes and potentiate or prolong the inflammatory response may have profound implications for the progression of oral diseases such as chronic periodontitis, where tissue destruction may be widespread. Moreover, it is increasingly recognized that chronic inflammation is a key component of tumor progression. Interaction between cancer cells and their microenvironment is mediated in large part by secreted factors such as chemokines, and serves to enhance the malignant phenotype in oral and other cancers. In this article, we will outline the biological and biochemical mechanisms of chemokine action in host-microbiome interactions in periodontal disease and in oral cancer, and how these may overlap and contribute to pathogenesis.",
keywords = "Chemokine, Host-pathogen interactions, Inflammation, Oral cancer, Periodontitis, Toll-like receptor",
author = "Sahingur, {Sinem Esra} and Yeudall, {William Andrew}",
year = "2015",
month = "1",
day = "1",
doi = "10.3389/fimmu.2015.00214",
language = "English (US)",
volume = "6",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Media S. A.",
number = "MAY",

}

TY - JOUR

T1 - Chemokine function in periodontal disease and oral cavity cancer

AU - Sahingur, Sinem Esra

AU - Yeudall, William Andrew

PY - 2015/1/1

Y1 - 2015/1/1

N2 - The chemotactic cytokines, or chemokines, comprise a superfamily of polypeptides with a wide range of activities that include recruitment of immune cells to sites of infection and inflammation, as well as stimulation of cell proliferation. As such, they function as antimicrobial molecules and play a central role in host defenses against pathogen challenge. However, their ability to recruit leukocytes and potentiate or prolong the inflammatory response may have profound implications for the progression of oral diseases such as chronic periodontitis, where tissue destruction may be widespread. Moreover, it is increasingly recognized that chronic inflammation is a key component of tumor progression. Interaction between cancer cells and their microenvironment is mediated in large part by secreted factors such as chemokines, and serves to enhance the malignant phenotype in oral and other cancers. In this article, we will outline the biological and biochemical mechanisms of chemokine action in host-microbiome interactions in periodontal disease and in oral cancer, and how these may overlap and contribute to pathogenesis.

AB - The chemotactic cytokines, or chemokines, comprise a superfamily of polypeptides with a wide range of activities that include recruitment of immune cells to sites of infection and inflammation, as well as stimulation of cell proliferation. As such, they function as antimicrobial molecules and play a central role in host defenses against pathogen challenge. However, their ability to recruit leukocytes and potentiate or prolong the inflammatory response may have profound implications for the progression of oral diseases such as chronic periodontitis, where tissue destruction may be widespread. Moreover, it is increasingly recognized that chronic inflammation is a key component of tumor progression. Interaction between cancer cells and their microenvironment is mediated in large part by secreted factors such as chemokines, and serves to enhance the malignant phenotype in oral and other cancers. In this article, we will outline the biological and biochemical mechanisms of chemokine action in host-microbiome interactions in periodontal disease and in oral cancer, and how these may overlap and contribute to pathogenesis.

KW - Chemokine

KW - Host-pathogen interactions

KW - Inflammation

KW - Oral cancer

KW - Periodontitis

KW - Toll-like receptor

UR - http://www.scopus.com/inward/record.url?scp=84934276094&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84934276094&partnerID=8YFLogxK

U2 - 10.3389/fimmu.2015.00214

DO - 10.3389/fimmu.2015.00214

M3 - Review article

AN - SCOPUS:84934276094

VL - 6

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

IS - MAY

M1 - 214

ER -