Chemokines and squamous cancer of the head and neck

Targets for therapeutic intervention?

William Andrew Yeudall, Hiroshi Miyazaki

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

The biological properties of squamous carcinoma cells are intimately regulated by a multitude of cytokines; and growth factors; the most well studied of these include epidermal growth factor receptor agonists and members of the transforming growth factor-β family. The recent explosion of research in the field of chemokine function as a mediator of tumor progression has led to the possibility that these small, immunomodulatory proteins also play key roles in squamous carcinogenesis and may, therefore, be potential targets for novel therapeutic approaches.

Original languageEnglish (US)
Pages (from-to)351-360
Number of pages10
JournalExpert Review of Anticancer Therapy
Volume7
Issue number3
DOIs
StatePublished - Mar 1 2007
Externally publishedYes

Fingerprint

Explosions
Transforming Growth Factors
Head and Neck Neoplasms
Chemokines
Epidermal Growth Factor Receptor
Squamous Cell Carcinoma
Intercellular Signaling Peptides and Proteins
Carcinogenesis
Cytokines
Research
Neoplasms
Proteins
Therapeutics

Keywords

  • Chemokine
  • Oral cancer
  • Receptor
  • Signal transduction
  • Squamous cell carcinoma
  • Targeted therapeutic
  • Tumor progression

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

Cite this

Chemokines and squamous cancer of the head and neck : Targets for therapeutic intervention? / Yeudall, William Andrew; Miyazaki, Hiroshi.

In: Expert Review of Anticancer Therapy, Vol. 7, No. 3, 01.03.2007, p. 351-360.

Research output: Contribution to journalReview article

@article{8e43d7f50e904985bb80b5def6440d1e,
title = "Chemokines and squamous cancer of the head and neck: Targets for therapeutic intervention?",
abstract = "The biological properties of squamous carcinoma cells are intimately regulated by a multitude of cytokines; and growth factors; the most well studied of these include epidermal growth factor receptor agonists and members of the transforming growth factor-β family. The recent explosion of research in the field of chemokine function as a mediator of tumor progression has led to the possibility that these small, immunomodulatory proteins also play key roles in squamous carcinogenesis and may, therefore, be potential targets for novel therapeutic approaches.",
keywords = "Chemokine, Oral cancer, Receptor, Signal transduction, Squamous cell carcinoma, Targeted therapeutic, Tumor progression",
author = "Yeudall, {William Andrew} and Hiroshi Miyazaki",
year = "2007",
month = "3",
day = "1",
doi = "10.1586/14737140.7.3.351",
language = "English (US)",
volume = "7",
pages = "351--360",
journal = "Expert Review of Anticancer Therapy",
issn = "1473-7140",
publisher = "Expert Reviews Ltd.",
number = "3",

}

TY - JOUR

T1 - Chemokines and squamous cancer of the head and neck

T2 - Targets for therapeutic intervention?

AU - Yeudall, William Andrew

AU - Miyazaki, Hiroshi

PY - 2007/3/1

Y1 - 2007/3/1

N2 - The biological properties of squamous carcinoma cells are intimately regulated by a multitude of cytokines; and growth factors; the most well studied of these include epidermal growth factor receptor agonists and members of the transforming growth factor-β family. The recent explosion of research in the field of chemokine function as a mediator of tumor progression has led to the possibility that these small, immunomodulatory proteins also play key roles in squamous carcinogenesis and may, therefore, be potential targets for novel therapeutic approaches.

AB - The biological properties of squamous carcinoma cells are intimately regulated by a multitude of cytokines; and growth factors; the most well studied of these include epidermal growth factor receptor agonists and members of the transforming growth factor-β family. The recent explosion of research in the field of chemokine function as a mediator of tumor progression has led to the possibility that these small, immunomodulatory proteins also play key roles in squamous carcinogenesis and may, therefore, be potential targets for novel therapeutic approaches.

KW - Chemokine

KW - Oral cancer

KW - Receptor

KW - Signal transduction

KW - Squamous cell carcinoma

KW - Targeted therapeutic

KW - Tumor progression

UR - http://www.scopus.com/inward/record.url?scp=33947682892&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33947682892&partnerID=8YFLogxK

U2 - 10.1586/14737140.7.3.351

DO - 10.1586/14737140.7.3.351

M3 - Review article

VL - 7

SP - 351

EP - 360

JO - Expert Review of Anticancer Therapy

JF - Expert Review of Anticancer Therapy

SN - 1473-7140

IS - 3

ER -