Chemokines and squamous cancer of the head and neck: Targets for therapeutic intervention?

William Andrew Yeudall, Hiroshi Miyazaki

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

The biological properties of squamous carcinoma cells are intimately regulated by a multitude of cytokines; and growth factors; the most well studied of these include epidermal growth factor receptor agonists and members of the transforming growth factor-β family. The recent explosion of research in the field of chemokine function as a mediator of tumor progression has led to the possibility that these small, immunomodulatory proteins also play key roles in squamous carcinogenesis and may, therefore, be potential targets for novel therapeutic approaches.

Original languageEnglish (US)
Pages (from-to)351-360
Number of pages10
JournalExpert Review of Anticancer Therapy
Volume7
Issue number3
DOIs
StatePublished - Mar 1 2007

Keywords

  • Chemokine
  • Oral cancer
  • Receptor
  • Signal transduction
  • Squamous cell carcinoma
  • Targeted therapeutic
  • Tumor progression

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

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