Chemokines/intercrines and central regulation of feeding

C. R. Plata-Salaman, J. P. Borkoski

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

Chemokines/intercrines are structurally and functionally related cytokines that induce specific actions on the immune system and are released in response to infection, inflammation, and trauma. These pathological processes are frequently accompanied with food intake suppression. In the present study, the action of chemokines/intercrines on the regulation of feeding was investigated using the intracerebroventricular microinfusion of chemokine/intercrine-α subfamily members [interleukin-8 (IL-8); growth- related cytokine/melanoma growth-stimulating activity (GRO-α/MGSA); platelet factor-4 (PF-4); β-thromboglobulin (β-TG); and interferon-inducible protein-10 (IP-10)] and β-subfamily members [monocyte chemotactic protein- 1/monocyte chemotactic and activating factor (MCP-1/MCAF); regulated upon activation normal T-cell expressed and presumably secreted (RANTES); macrophage inflammatory protein-1α (MIP-1α); and macrophage inflammatory protein-1β (MIP-1β)]. The doses administered were 1.0, 20, and 100 ng/rat of the chemokine/intercrine. The intracerebroventricular administration of three members of the α-subfamily (IL-8, PF-4, and IP-10) and two members of the β-subfamily (MCP-1/MCAF and RANTES) decreased the short-term (2-h) food intake. These effective chemokines/intercrines, however, were significantly less potent than IL-1β in decreasing feeding. The results support the hypothesis that only a subset of immunomodulators released during pathological processes may participate in the regulation of feeding with different potencies.

Original languageEnglish (US)
Pages (from-to)R1711-R1715
JournalAM.J.PHYSIOL.
Volume266
Issue number5 part 2
DOIs
StatePublished - 1994
Externally publishedYes

Keywords

  • behavior
  • cytokine
  • food intake
  • growth factor
  • immune system
  • immunomodulator
  • interleukin
  • intracerebroventricular
  • nervous system
  • neuroimmunology
  • rat

ASJC Scopus subject areas

  • Physiology

Fingerprint Dive into the research topics of 'Chemokines/intercrines and central regulation of feeding'. Together they form a unique fingerprint.

  • Cite this

    Plata-Salaman, C. R., & Borkoski, J. P. (1994). Chemokines/intercrines and central regulation of feeding. AM.J.PHYSIOL., 266(5 part 2), R1711-R1715. https://doi.org/10.1152/ajpregu.1994.266.5.r1711