Chemokines/intercrines and central regulation of feeding

C. R. Plata-Salaman, J. P. Borkoski

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Chemokines/intercrines are structurally and functionally related cytokines that induce specific actions on the immune system and are released in response to infection, inflammation, and trauma. These pathological processes are frequently accompanied with food intake suppression. In the present study, the action of chemokines/intercrines on the regulation of feeding was investigated using the intracerebroventricular microinfusion of chemokine/intercrine-α subfamily members [interleukin-8 (IL-8); growth- related cytokine/melanoma growth-stimulating activity (GRO-α/MGSA); platelet factor-4 (PF-4); β-thromboglobulin (β-TG); and interferon-inducible protein-10 (IP-10)] and β-subfamily members [monocyte chemotactic protein- 1/monocyte chemotactic and activating factor (MCP-1/MCAF); regulated upon activation normal T-cell expressed and presumably secreted (RANTES); macrophage inflammatory protein-1α (MIP-1α); and macrophage inflammatory protein-1β (MIP-1β)]. The doses administered were 1.0, 20, and 100 ng/rat of the chemokine/intercrine. The intracerebroventricular administration of three members of the α-subfamily (IL-8, PF-4, and IP-10) and two members of the β-subfamily (MCP-1/MCAF and RANTES) decreased the short-term (2-h) food intake. These effective chemokines/intercrines, however, were significantly less potent than IL-1β in decreasing feeding. The results support the hypothesis that only a subset of immunomodulators released during pathological processes may participate in the regulation of feeding with different potencies.

Original languageEnglish (US)
JournalAM.J.PHYSIOL.
Volume266
Issue number5 part 2
StatePublished - 1994
Externally publishedYes

Fingerprint

Chemokines
Chemokine CCL2
Platelet Factor 4
Macrophage Inflammatory Proteins
Pathologic Processes
Interleukin-8
Eating
Chemokine CXCL10
Cytokines
T-Lymphocytes
Immunologic Factors
Growth
Interleukin-1
Immune System
Melanoma
Inflammation
Wounds and Injuries
Infection

Keywords

  • behavior
  • cytokine
  • food intake
  • growth factor
  • immune system
  • immunomodulator
  • interleukin
  • intracerebroventricular
  • nervous system
  • neuroimmunology
  • rat

ASJC Scopus subject areas

  • Physiology

Cite this

Plata-Salaman, C. R., & Borkoski, J. P. (1994). Chemokines/intercrines and central regulation of feeding. AM.J.PHYSIOL., 266(5 part 2).

Chemokines/intercrines and central regulation of feeding. / Plata-Salaman, C. R.; Borkoski, J. P.

In: AM.J.PHYSIOL., Vol. 266, No. 5 part 2, 1994.

Research output: Contribution to journalArticle

Plata-Salaman, CR & Borkoski, JP 1994, 'Chemokines/intercrines and central regulation of feeding', AM.J.PHYSIOL., vol. 266, no. 5 part 2.
Plata-Salaman CR, Borkoski JP. Chemokines/intercrines and central regulation of feeding. AM.J.PHYSIOL. 1994;266(5 part 2).
Plata-Salaman, C. R. ; Borkoski, J. P. / Chemokines/intercrines and central regulation of feeding. In: AM.J.PHYSIOL. 1994 ; Vol. 266, No. 5 part 2.
@article{26d3e3f689f1469a9954aa1f9425654e,
title = "Chemokines/intercrines and central regulation of feeding",
abstract = "Chemokines/intercrines are structurally and functionally related cytokines that induce specific actions on the immune system and are released in response to infection, inflammation, and trauma. These pathological processes are frequently accompanied with food intake suppression. In the present study, the action of chemokines/intercrines on the regulation of feeding was investigated using the intracerebroventricular microinfusion of chemokine/intercrine-α subfamily members [interleukin-8 (IL-8); growth- related cytokine/melanoma growth-stimulating activity (GRO-α/MGSA); platelet factor-4 (PF-4); β-thromboglobulin (β-TG); and interferon-inducible protein-10 (IP-10)] and β-subfamily members [monocyte chemotactic protein- 1/monocyte chemotactic and activating factor (MCP-1/MCAF); regulated upon activation normal T-cell expressed and presumably secreted (RANTES); macrophage inflammatory protein-1α (MIP-1α); and macrophage inflammatory protein-1β (MIP-1β)]. The doses administered were 1.0, 20, and 100 ng/rat of the chemokine/intercrine. The intracerebroventricular administration of three members of the α-subfamily (IL-8, PF-4, and IP-10) and two members of the β-subfamily (MCP-1/MCAF and RANTES) decreased the short-term (2-h) food intake. These effective chemokines/intercrines, however, were significantly less potent than IL-1β in decreasing feeding. The results support the hypothesis that only a subset of immunomodulators released during pathological processes may participate in the regulation of feeding with different potencies.",
keywords = "behavior, cytokine, food intake, growth factor, immune system, immunomodulator, interleukin, intracerebroventricular, nervous system, neuroimmunology, rat",
author = "Plata-Salaman, {C. R.} and Borkoski, {J. P.}",
year = "1994",
language = "English (US)",
volume = "266",
journal = "American Journal of Physiology - Heart and Circulatory Physiology",
issn = "0363-6135",
publisher = "American Physiological Society",
number = "5 part 2",

}

TY - JOUR

T1 - Chemokines/intercrines and central regulation of feeding

AU - Plata-Salaman, C. R.

AU - Borkoski, J. P.

PY - 1994

Y1 - 1994

N2 - Chemokines/intercrines are structurally and functionally related cytokines that induce specific actions on the immune system and are released in response to infection, inflammation, and trauma. These pathological processes are frequently accompanied with food intake suppression. In the present study, the action of chemokines/intercrines on the regulation of feeding was investigated using the intracerebroventricular microinfusion of chemokine/intercrine-α subfamily members [interleukin-8 (IL-8); growth- related cytokine/melanoma growth-stimulating activity (GRO-α/MGSA); platelet factor-4 (PF-4); β-thromboglobulin (β-TG); and interferon-inducible protein-10 (IP-10)] and β-subfamily members [monocyte chemotactic protein- 1/monocyte chemotactic and activating factor (MCP-1/MCAF); regulated upon activation normal T-cell expressed and presumably secreted (RANTES); macrophage inflammatory protein-1α (MIP-1α); and macrophage inflammatory protein-1β (MIP-1β)]. The doses administered were 1.0, 20, and 100 ng/rat of the chemokine/intercrine. The intracerebroventricular administration of three members of the α-subfamily (IL-8, PF-4, and IP-10) and two members of the β-subfamily (MCP-1/MCAF and RANTES) decreased the short-term (2-h) food intake. These effective chemokines/intercrines, however, were significantly less potent than IL-1β in decreasing feeding. The results support the hypothesis that only a subset of immunomodulators released during pathological processes may participate in the regulation of feeding with different potencies.

AB - Chemokines/intercrines are structurally and functionally related cytokines that induce specific actions on the immune system and are released in response to infection, inflammation, and trauma. These pathological processes are frequently accompanied with food intake suppression. In the present study, the action of chemokines/intercrines on the regulation of feeding was investigated using the intracerebroventricular microinfusion of chemokine/intercrine-α subfamily members [interleukin-8 (IL-8); growth- related cytokine/melanoma growth-stimulating activity (GRO-α/MGSA); platelet factor-4 (PF-4); β-thromboglobulin (β-TG); and interferon-inducible protein-10 (IP-10)] and β-subfamily members [monocyte chemotactic protein- 1/monocyte chemotactic and activating factor (MCP-1/MCAF); regulated upon activation normal T-cell expressed and presumably secreted (RANTES); macrophage inflammatory protein-1α (MIP-1α); and macrophage inflammatory protein-1β (MIP-1β)]. The doses administered were 1.0, 20, and 100 ng/rat of the chemokine/intercrine. The intracerebroventricular administration of three members of the α-subfamily (IL-8, PF-4, and IP-10) and two members of the β-subfamily (MCP-1/MCAF and RANTES) decreased the short-term (2-h) food intake. These effective chemokines/intercrines, however, were significantly less potent than IL-1β in decreasing feeding. The results support the hypothesis that only a subset of immunomodulators released during pathological processes may participate in the regulation of feeding with different potencies.

KW - behavior

KW - cytokine

KW - food intake

KW - growth factor

KW - immune system

KW - immunomodulator

KW - interleukin

KW - intracerebroventricular

KW - nervous system

KW - neuroimmunology

KW - rat

UR - http://www.scopus.com/inward/record.url?scp=0028246585&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028246585&partnerID=8YFLogxK

M3 - Article

VL - 266

JO - American Journal of Physiology - Heart and Circulatory Physiology

JF - American Journal of Physiology - Heart and Circulatory Physiology

SN - 0363-6135

IS - 5 part 2

ER -