Chemotherapy for acute lymphocytic leukemia: Cognitive and academic sequelae

Ronald T. Brown, Avi Madan-Swain, Ray Pais, Richard G. Lambert, Sandra Sexson, Abdel Ragab

Research output: Contribution to journalArticlepeer-review

85 Scopus citations


Iatrogenic cognitive impairments have been reported for survivors of childhood leukemia after prophylactic central nervous system therapy with craniospinal radiation. To determine whether chemotherapy alone might be a source of central nervous system damage, we assessed in a cross-sectional design the cognitive and academic functioning of 48 children with acute lymphocytic leukemia who were at various stages in their treatment or who had completed treatment. The off-therapy patients who had completed a 3-year course of chemotherapy were more impaired in tasks of higher-order cognitive functioning than were those children whose leukemia had been newly diagnosed and those children whose diagnoses had been 1 years earlier. Off-therapy patients also had concomitant diagnosable learning disabilities in mathematics. We recommend appropriate liaison and special education placements, as well as continued evaluation of cognitive and learning functioning of children treated for moderate-risk acute lymphocytic leukemia who receive chemotherapy alone.

Original languageEnglish (US)
Pages (from-to)885-889
Number of pages5
JournalThe Journal of Pediatrics
Issue number6
StatePublished - Dec 1992
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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