Childhood obesity, bone development, and cardiometabolic risk factors

Research output: Contribution to journalReview article

33 Citations (Scopus)

Abstract

Osteoporosis and obesity are both major public health concerns. It has long been considered that these are distinct disorders rarely found in the same individual; however, emerging evidence supports an important interaction between adipose tissue and the skeleton. Whereas overweight per se may augment bone strength, animal studies suggest that the metabolic impairment that accompanies obesity is detrimental to bone. Obesity during childhood, a critical time for bone development, likely has profound and lasting effects on bone strength and fracture risk. This notion has received little attention in children and results are mixed, with studies reporting that bone strength development is enhanced or impaired by obesity. Whether obesity is a risk factor for osteoporosis or childhood bone health, in general, remains an important clinical question. Here, we will focus on clarifying the controversial relationships between childhood obesity and bone strength development, and provide insights into potential mechanisms that may regulate the effect of excess adiposity on bone.

Original languageEnglish (US)
Pages (from-to)52-63
Number of pages12
JournalMolecular and Cellular Endocrinology
Volume410
DOIs
StatePublished - Jul 5 2015

Fingerprint

Pediatric Obesity
Bone Development
Bone
Obesity
Bone and Bones
Osteoporosis
Bone Fractures
Adiposity
Skeleton
Adipose Tissue
Public Health
Health
Public health
Animals
Tissue

Keywords

  • Bone
  • Children
  • Fat
  • Inflammation
  • Insulin resistance
  • Obesity

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Cite this

Childhood obesity, bone development, and cardiometabolic risk factors. / Pollock, Norman K.

In: Molecular and Cellular Endocrinology, Vol. 410, 05.07.2015, p. 52-63.

Research output: Contribution to journalReview article

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