Abstract
A study of chirally selective interaction in the stirred crystallization of glutamic acid and lysine is presented. The crystallization of S-glutamic acid is influenced by the presence of S-lysine but not R-lysine. Crystal nuclei in stirred systems are produced due to secondary nucleation. Secondary nucleation is an autocatalytic process in which a crystal produces secondary nuclei due to fluid motion, and due to crystal stirrer and crystal-crystal collisions. As a result of this autocatalysis, small fluctuations in the nucleation rates are amplified and the kinetics show a marked stochastic behavior. We investigate the stochastic behavior in detail and propose a kinetic mechanism that explains both the increase and the statistical distribution of the crystallization times of S-glutamic acid due to the presence of S-Lysine.
Original language | English (US) |
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Pages (from-to) | 238-245 |
Number of pages | 8 |
Journal | Chirality |
Volume | 10 |
Issue number | 3 |
DOIs | |
State | Published - 1998 |
Externally published | Yes |
Keywords
- Amino acid crystallization
- Chiral selectivity
- Molecular recognition
- Stochastic kinetics
ASJC Scopus subject areas
- Analytical Chemistry
- Catalysis
- Pharmacology
- Drug Discovery
- Spectroscopy
- Organic Chemistry