Chiral interaction and stochastic kinetics in stirred crystallization of amino acids

Dilip K. Kondepudi, Mustafa Culha

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

A study of chirally selective interaction in the stirred crystallization of glutamic acid and lysine is presented. The crystallization of S-glutamic acid is influenced by the presence of S-lysine but not R-lysine. Crystal nuclei in stirred systems are produced due to secondary nucleation. Secondary nucleation is an autocatalytic process in which a crystal produces secondary nuclei due to fluid motion, and due to crystal stirrer and crystal-crystal collisions. As a result of this autocatalysis, small fluctuations in the nucleation rates are amplified and the kinetics show a marked stochastic behavior. We investigate the stochastic behavior in detail and propose a kinetic mechanism that explains both the increase and the statistical distribution of the crystallization times of S-glutamic acid due to the presence of S-Lysine.

Original languageEnglish (US)
Pages (from-to)238-245
Number of pages8
JournalChirality
Volume10
Issue number3
DOIs
StatePublished - 1998
Externally publishedYes

Keywords

  • Amino acid crystallization
  • Chiral selectivity
  • Molecular recognition
  • Stochastic kinetics

ASJC Scopus subject areas

  • Analytical Chemistry
  • Catalysis
  • Pharmacology
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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