One hundred ten couples were evaluated for reproductive failure from 1978 to 1981. Cytogenetic findings include a chromosome variant in 13 couples (12%) and a gross structural rearrangement in 6 couples. The Chromosome Polymorphism Group was subdivided into Subgroup I, presenting chromosome variants with additional heterochromatin material, and Subgroup II demonstrating inversion of the pericentromeric heterochromatin: pericentric inversion (9). Six of the seven couples of Subgroup I (85%) achieved a subsequent successful pregnancy, as compared with one of the six couples of Subgroup II (17%). Pericentric inversion (9) may have an adverse effect on reproductive performance. Karyotypes of the abortus material are critical for determination of the causal relationship of chromosome polymorphism and reproductive failure.
ASJC Scopus subject areas
- Obstetrics and Gynecology